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Targeted siRNA nanocarrier: a platform technology for cancer treatment

The small arginine-rich protein protamine condenses complete genomic DNA into the sperm head. Here, we applied its high RNA binding capacity for spontaneous electrostatic assembly of therapeutic nanoparticles decorated with tumour-cell-specific antibodies for efficiently targeting siRNA. Fluorescenc...

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Detalles Bibliográficos
Autores principales:	Bäumer, Nicole, Tiemann, Jessica, Scheller, Annika, Meyer, Theresa, Wittmann, Lisa, Suburu, Matias Ezequiel Gutierrez, Greune, Lilo, Peipp, Matthias, Kellmann, Neele, Gumnior, Annika, Brand, Caroline, Hartmann, Wolfgang, Rossig, Claudia, Müller-Tidow, Carsten, Neri, Dario, Strassert, Cristian A., Rüter, Christian, Dersch, Petra, Lenz, Georg, Koeffler, H. Phillip, Berdel, Wolfgang E., Bäumer, Sebastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993695/ https://www.ncbi.nlm.nih.gov/pubmed/35220407 http://dx.doi.org/10.1038/s41388-022-02241-w

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