A biaxial tensional model for early vertebrate morphogenesis

ABSTRACT: We propose a simple biaxial tensional model which is able to reproduce at a qualitative level several aspects of early stages of vertebrate morphogenesis. The model is based on subsequent excitable contractions of an orthoradial and periclinal (radial) set of contracting lines, which gener...

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Detalles Bibliográficos
Autores principales: Fleury, Vincent, Abourachid, Anick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Regular Article - Living Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993754/
https://www.ncbi.nlm.nih.gov/pubmed/35394228
http://dx.doi.org/10.1140/epje/s10189-022-00184-4
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author Fleury, Vincent
Abourachid, Anick
author_facet Fleury, Vincent
Abourachid, Anick
author_sort Fleury, Vincent
collection PubMed
description ABSTRACT: We propose a simple biaxial tensional model which is able to reproduce at a qualitative level several aspects of early stages of vertebrate morphogenesis. The model is based on subsequent excitable contractions of an orthoradial and periclinal (radial) set of contracting lines, which generate first the basic embryonic pattern (a motile tube), and second the lateral orifices such as ears, eyes, mouth, gills, etc. An important aspect of the model is the self-arresting character of the process, akin to wound healing. At later stages, the biaxial lines may also work in extension, and this generates a developmental feedback which is quadratic with respect to curvature. GRAPHIC ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1140/epje/s10189-022-00184-4.
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spelling pubmed-89937542022-04-22 A biaxial tensional model for early vertebrate morphogenesis Fleury, Vincent Abourachid, Anick Eur Phys J E Soft Matter Regular Article - Living Systems ABSTRACT: We propose a simple biaxial tensional model which is able to reproduce at a qualitative level several aspects of early stages of vertebrate morphogenesis. The model is based on subsequent excitable contractions of an orthoradial and periclinal (radial) set of contracting lines, which generate first the basic embryonic pattern (a motile tube), and second the lateral orifices such as ears, eyes, mouth, gills, etc. An important aspect of the model is the self-arresting character of the process, akin to wound healing. At later stages, the biaxial lines may also work in extension, and this generates a developmental feedback which is quadratic with respect to curvature. GRAPHIC ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1140/epje/s10189-022-00184-4. Springer Berlin Heidelberg 2022-04-08 2022 /pmc/articles/PMC8993754/ /pubmed/35394228 http://dx.doi.org/10.1140/epje/s10189-022-00184-4 Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Regular Article - Living Systems
Fleury, Vincent
Abourachid, Anick
A biaxial tensional model for early vertebrate morphogenesis
title A biaxial tensional model for early vertebrate morphogenesis
title_full A biaxial tensional model for early vertebrate morphogenesis
title_fullStr A biaxial tensional model for early vertebrate morphogenesis
title_full_unstemmed A biaxial tensional model for early vertebrate morphogenesis
title_short A biaxial tensional model for early vertebrate morphogenesis
title_sort biaxial tensional model for early vertebrate morphogenesis
topic Regular Article - Living Systems
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993754/
https://www.ncbi.nlm.nih.gov/pubmed/35394228
http://dx.doi.org/10.1140/epje/s10189-022-00184-4
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