Cargando…

Tumor blood flow and apparent diffusion coefficient histogram analysis for differentiating malignant salivary tumors from pleomorphic adenomas and Warthin’s tumors

We aimed to assess the combined diagnostic value of apparent diffusion coefficient (ADC) and tumor blood flow (TBF) obtained by pseudocontinuous arterial spin labeling (pCASL) for differentiating malignant tumors (MTs) in salivary glands from pleomorphic adenomas (PAs) and Warthin’s tumors (WTs). We...

Descripción completa

Detalles Bibliográficos
Autores principales: Tanaka, Fumine, Umino, Maki, Maeda, Masayuki, Nakayama, Ryohei, Inoue, Katsuhiro, Kogue, Ryota, Obara, Makoto, Sakuma, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993800/
https://www.ncbi.nlm.nih.gov/pubmed/35396374
http://dx.doi.org/10.1038/s41598-022-09968-2
_version_ 1784683977852846080
author Tanaka, Fumine
Umino, Maki
Maeda, Masayuki
Nakayama, Ryohei
Inoue, Katsuhiro
Kogue, Ryota
Obara, Makoto
Sakuma, Hajime
author_facet Tanaka, Fumine
Umino, Maki
Maeda, Masayuki
Nakayama, Ryohei
Inoue, Katsuhiro
Kogue, Ryota
Obara, Makoto
Sakuma, Hajime
author_sort Tanaka, Fumine
collection PubMed
description We aimed to assess the combined diagnostic value of apparent diffusion coefficient (ADC) and tumor blood flow (TBF) obtained by pseudocontinuous arterial spin labeling (pCASL) for differentiating malignant tumors (MTs) in salivary glands from pleomorphic adenomas (PAs) and Warthin’s tumors (WTs). We used pCASL imaging and ADC map to evaluate 65 patients, including 16 with MT, 30 with PA, and 19 with WT. We evaluated all tumors by histogram analyses and compared various characteristics by one-way analysis of variance followed by Tukey post-hoc tests. Diagnostic performance was evaluated by receiver operating characteristic (ROC) curve analysis. There were significant differences in the mean, 50th, 75th, and 90th percentiles of TBF among the tumor types, in the mean TBFs (mL/100 g/min) between MTs (57.47 ± 35.14) and PAs (29.88 ± 22.53, p = 0.039) and between MTs and WTs (119.31 ± 50.11, p < 0.001), as well as in the mean ADCs (× 10(−3) mm(2)/s) between MTs (1.08 ± 0.28) and PAs (1.60 ± 0.34, p < 0.001), but not in the mean ADCs between MTs and WTs (0.87 ± 0.23, p = 0.117). In the ROC curve analysis, the highest areas under the curves (AUCs) were achieved by the 10th and 25th percentiles of ADC (AUC = 0.885) for differentiating MTs from PAs and the 50th percentile of TBF (AUC = 0.855) for differentiating MTs from WTs. The AUCs of TBF, ADC, and combination of TBF and ADC were 0.850, 0.885, and 0.950 for MTs and PAs differentiation and 0.855, 0.814, and 0.905 for MTs and WTs differentiation, respectively. The combination of TBF and ADC evaluated by histogram analysis may help differentiate salivary gland MTs from PAs and WTs.
format Online
Article
Text
id pubmed-8993800
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-89938002022-04-11 Tumor blood flow and apparent diffusion coefficient histogram analysis for differentiating malignant salivary tumors from pleomorphic adenomas and Warthin’s tumors Tanaka, Fumine Umino, Maki Maeda, Masayuki Nakayama, Ryohei Inoue, Katsuhiro Kogue, Ryota Obara, Makoto Sakuma, Hajime Sci Rep Article We aimed to assess the combined diagnostic value of apparent diffusion coefficient (ADC) and tumor blood flow (TBF) obtained by pseudocontinuous arterial spin labeling (pCASL) for differentiating malignant tumors (MTs) in salivary glands from pleomorphic adenomas (PAs) and Warthin’s tumors (WTs). We used pCASL imaging and ADC map to evaluate 65 patients, including 16 with MT, 30 with PA, and 19 with WT. We evaluated all tumors by histogram analyses and compared various characteristics by one-way analysis of variance followed by Tukey post-hoc tests. Diagnostic performance was evaluated by receiver operating characteristic (ROC) curve analysis. There were significant differences in the mean, 50th, 75th, and 90th percentiles of TBF among the tumor types, in the mean TBFs (mL/100 g/min) between MTs (57.47 ± 35.14) and PAs (29.88 ± 22.53, p = 0.039) and between MTs and WTs (119.31 ± 50.11, p < 0.001), as well as in the mean ADCs (× 10(−3) mm(2)/s) between MTs (1.08 ± 0.28) and PAs (1.60 ± 0.34, p < 0.001), but not in the mean ADCs between MTs and WTs (0.87 ± 0.23, p = 0.117). In the ROC curve analysis, the highest areas under the curves (AUCs) were achieved by the 10th and 25th percentiles of ADC (AUC = 0.885) for differentiating MTs from PAs and the 50th percentile of TBF (AUC = 0.855) for differentiating MTs from WTs. The AUCs of TBF, ADC, and combination of TBF and ADC were 0.850, 0.885, and 0.950 for MTs and PAs differentiation and 0.855, 0.814, and 0.905 for MTs and WTs differentiation, respectively. The combination of TBF and ADC evaluated by histogram analysis may help differentiate salivary gland MTs from PAs and WTs. Nature Publishing Group UK 2022-04-08 /pmc/articles/PMC8993800/ /pubmed/35396374 http://dx.doi.org/10.1038/s41598-022-09968-2 Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Tanaka, Fumine
Umino, Maki
Maeda, Masayuki
Nakayama, Ryohei
Inoue, Katsuhiro
Kogue, Ryota
Obara, Makoto
Sakuma, Hajime
Tumor blood flow and apparent diffusion coefficient histogram analysis for differentiating malignant salivary tumors from pleomorphic adenomas and Warthin’s tumors
title Tumor blood flow and apparent diffusion coefficient histogram analysis for differentiating malignant salivary tumors from pleomorphic adenomas and Warthin’s tumors
title_full Tumor blood flow and apparent diffusion coefficient histogram analysis for differentiating malignant salivary tumors from pleomorphic adenomas and Warthin’s tumors
title_fullStr Tumor blood flow and apparent diffusion coefficient histogram analysis for differentiating malignant salivary tumors from pleomorphic adenomas and Warthin’s tumors
title_full_unstemmed Tumor blood flow and apparent diffusion coefficient histogram analysis for differentiating malignant salivary tumors from pleomorphic adenomas and Warthin’s tumors
title_short Tumor blood flow and apparent diffusion coefficient histogram analysis for differentiating malignant salivary tumors from pleomorphic adenomas and Warthin’s tumors
title_sort tumor blood flow and apparent diffusion coefficient histogram analysis for differentiating malignant salivary tumors from pleomorphic adenomas and warthin’s tumors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993800/
https://www.ncbi.nlm.nih.gov/pubmed/35396374
http://dx.doi.org/10.1038/s41598-022-09968-2
work_keys_str_mv AT tanakafumine tumorbloodflowandapparentdiffusioncoefficienthistogramanalysisfordifferentiatingmalignantsalivarytumorsfrompleomorphicadenomasandwarthinstumors
AT uminomaki tumorbloodflowandapparentdiffusioncoefficienthistogramanalysisfordifferentiatingmalignantsalivarytumorsfrompleomorphicadenomasandwarthinstumors
AT maedamasayuki tumorbloodflowandapparentdiffusioncoefficienthistogramanalysisfordifferentiatingmalignantsalivarytumorsfrompleomorphicadenomasandwarthinstumors
AT nakayamaryohei tumorbloodflowandapparentdiffusioncoefficienthistogramanalysisfordifferentiatingmalignantsalivarytumorsfrompleomorphicadenomasandwarthinstumors
AT inouekatsuhiro tumorbloodflowandapparentdiffusioncoefficienthistogramanalysisfordifferentiatingmalignantsalivarytumorsfrompleomorphicadenomasandwarthinstumors
AT kogueryota tumorbloodflowandapparentdiffusioncoefficienthistogramanalysisfordifferentiatingmalignantsalivarytumorsfrompleomorphicadenomasandwarthinstumors
AT obaramakoto tumorbloodflowandapparentdiffusioncoefficienthistogramanalysisfordifferentiatingmalignantsalivarytumorsfrompleomorphicadenomasandwarthinstumors
AT sakumahajime tumorbloodflowandapparentdiffusioncoefficienthistogramanalysisfordifferentiatingmalignantsalivarytumorsfrompleomorphicadenomasandwarthinstumors