Cargando…

Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia

Most cancer cells have high need for nicotinamide adenine dinucleotide (NAD(+)) to sustain their survival. This led to the development of inhibitors of nicotinamide (NAM) phosphoribosyltransferase (NAMPT), the rate-limiting NAD(+) biosynthesis enzyme from NAM. Such inhibitors kill cancer cells in pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	ElMokh, Oussama, Matsumoto, Saki, Biniecka, Paulina, Bellotti, Axel, Schaeuble, Karin, Piacente, Francesco, Gallart-Ayala, Hector, Ivanisevic, Julijana, Stamenkovic, Ivan, Nencioni, Alessio, Nahimana, Aimable, Duchosal, Michel A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993809/ https://www.ncbi.nlm.nih.gov/pubmed/35396381 http://dx.doi.org/10.1038/s41419-022-04763-3

Ejemplares similares

Nicotinaldehyde, a Novel Precursor of NAD Biosynthesis, Abrogates the Anti-Cancer Activity of an NAD-Lowering Agent in Leukemia
por: Matsumoto, Saki, et al.
Publicado: (2023)

Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent
por: Cloux, Anne-Julie, et al.
Publicado: (2019)

Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies
por: Biniecka, Paulina, et al.
Publicado: (2023)

Sex‐specific alterations in NAD+ metabolism in 3xTg Alzheimer’s disease mouse brain assessed by quantitative targeted LC‐MS
por: van der Velpen, Vera, et al.
Publicado: (2021)

Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery
por: Ghanem, Moustafa S., et al.
Publicado: (2022)

Single-Step Extraction Coupled with Targeted HILIC-MS/MS Approach for Comprehensive Analysis of Human Plasma Lipidome and Polar Metabolome
por: Medina, Jessica, et al.
Publicado: (2020)

Experimental evolution of metabolism under nutrient restriction: enhanced amino acid catabolism and a key role of branched-chain amino acids
por: Cavigliasso, Fanny, et al.
Publicado: (2023)

Activation of Bone Marrow-Derived Cells Angiotensin (Ang) II Type 1 Receptor by Ang II Promotes Atherosclerotic Plaque Vulnerability
por: Pellegrin, Maxime, et al.
Publicado: (2018)

Evolutionary adaptation to juvenile malnutrition impacts adult metabolism and impairs adult fitness in Drosophila
por: Erkosar, Berra, et al.
Publicado: (2023)

Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD(+) and SIRT3
por: Masgras, Ionica, et al.
Publicado: (2022)

Advances in NAD-Lowering Agents for Cancer Treatment
por: Ghanem, Moustafa S., et al.
Publicado: (2021)

How Ceramides Orchestrate Cardiometabolic Health—An Ode to Physically Active Living
por: Carrard, Justin, et al.
Publicado: (2021)

Molecular insights into sex-specific metabolic alterations in Alzheimer’s mouse brain using multi-omics approach
por: Strefeler, Abigail, et al.
Publicado: (2023)

PIK3CA(H1047R)-induced paradoxical ERK activation results in resistance to BRAF(V600E) specific inhibitors in BRAF(V600E) PIK3CA(H1047R) double mutant thyroid tumors
por: Roelli, Matthias A., et al.
Publicado: (2017)

LC-HRMS data as a result of untargeted metabolomic profiling of human cerebrospinal fluid
por: Mehl, Florence, et al.
Publicado: (2018)

A novel anti-CD19 monoclonal antibody (GBR 401) with high killing activity against B cell malignancies
por: Breton, Caroline S, et al.
Publicado: (2014)

Combined MEK and Pi3′-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo
por: ElMokh, Oussama, et al.
Publicado: (2017)

Author Correction: Mechanistic insights into bacterial metabolic reprogramming from omics-integrated genome-scale models
por: Hadadi, Noushin, et al.
Publicado: (2020)

Mechanistic insights into bacterial metabolic reprogramming from omics-integrated genome-scale models
por: Hadadi, Noushin, et al.
Publicado: (2020)

The metabolic signature of cardiorespiratory fitness: a protocol for a systematic review and meta-analysis
por: Carrard, Justin, et al.
Publicado: (2021)

The Metabolic Signature of Cardiorespiratory Fitness: A Systematic Review
por: Carrard, Justin, et al.
Publicado: (2021)

Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model
por: Sociali, Giovanna, et al.
Publicado: (2015)

Systemic and central nervous system metabolic alterations in Alzheimer’s disease
por: van der Velpen, Vera, et al.
Publicado: (2019)

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles
por: Cianciaruso, Chiara, et al.
Publicado: (2019)

Metabolic View on Human Healthspan: A Lipidome-Wide Association Study
por: Carrard, Justin, et al.
Publicado: (2021)

Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells’ vulnerability to DNA-damaging agents
por: Cagnetta, Antonia, et al.
Publicado: (2018)

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy
por: Laurila, Pirkka-Pekka, et al.
Publicado: (2022)

De novo NAD(+) synthesis enhances mitochondrial function and improves health
por: Katsyuba, Elena, et al.
Publicado: (2018)

Metabolic Impairment in Coronary Artery Disease: Elevated Serum Acylcarnitines Under the Spotlights
por: Gander, Joséphine, et al.
Publicado: (2021)

Investigating the circulating sphingolipidome response to a single high-intensity interval training session within healthy females and males in their twenties (SphingoHIIT): Protocol for a randomised controlled trial
por: Carrard, Justin, et al.
Publicado: (2023)

Crippled Children's Hampers
por: Treloar, W. P.
Publicado: (1906)

From Samples to Insights into Metabolism: Uncovering Biologically Relevant Information in LC-HRMS Metabolomics Data
por: Ivanisevic, Julijana, et al.
Publicado: (2019)

The fate of orally administered sialic acid: First insights from patients with N-acetylneuraminic acid synthase deficiency and control subjects
por: Tran, Christel, et al.
Publicado: (2021)

A combination of plasma membrane sterol biosynthesis and autophagy is required for shade-induced hypocotyl elongation
por: Ince, Yetkin Çaka, et al.
Publicado: (2022)

Molecular Evidence of Pneumocystis Transmission in Pediatric Transplant Unit
por: Höcker, Britta, et al.
Publicado: (2005)

Payoff information hampers the evolution of cooperation
por: Huck, Steffen, et al.
Publicado: (2017)

Legitimate Dental Practice Hampered by Law
Publicado: (1898)

PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition
por: Triscott, Joanna, et al.
Publicado: (2023)

High Expression Hampers Horizontal Gene Transfer
por: Park, Chungoo, et al.
Publicado: (2012)

Are improper kinetic models hampering drug development?
por: Walsh, Ryan
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_h4jdsjqfmcd8g0ikrrkat5t19g