ROCK2-induced metabolic rewiring in diabetic podocytopathy

Loss of podocytes is a common feature of diabetic renal injury and a key contributor to the development of albuminuria. We found that podocyte Rho associated coiled-coil containing protein kinase 2 (ROCK2) is activated in rodent models and patients with diabetes. Mice that lacked ROCK2 only in podoc...

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Detalles Bibliográficos
Autores principales: Matoba, Keiichiro, Takeda, Yusuke, Nagai, Yosuke, Sekiguchi, Kensuke, Ukichi, Rikako, Takahashi, Hiroshi, Aizawa, Daisuke, Ikegami, Masahiro, Tachibana, Toshiaki, Kawanami, Daiji, Kanazawa, Yasushi, Yokota, Tamotsu, Utsunomiya, Kazunori, Nishimura, Rimei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993857/
https://www.ncbi.nlm.nih.gov/pubmed/35396346
http://dx.doi.org/10.1038/s42003-022-03300-4

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