Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels

Circulating total-tau levels can be used as an endophenotype to identify genetic risk factors for tauopathies and related neurological disorders. Here, we confirmed and better characterized the association of the 17q21 MAPT locus with circulating total-tau in 14,721 European participants and identif...

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Detalles Bibliográficos
Autores principales: Sarnowski, Chloé, Ghanbari, Mohsen, Bis, Joshua C., Logue, Mark, Fornage, Myriam, Mishra, Aniket, Ahmad, Shahzad, Beiser, Alexa S., Boerwinkle, Eric, Bouteloup, Vincent, Chouraki, Vincent, Cupples, L Adrienne, Damotte, Vincent, DeCarli, Charles S., DeStefano, Anita L., Djoussé, Luc, Fohner, Alison E., Franz, Carol E., Kautz, Tiffany F., Lambert, Jean-Charles, Lyons, Michael J., Mosley, Thomas H., Mukamal, Kenneth J., Pase, Matthew P., Portilla Fernandez, Eliana C., Rissman, Robert A., Satizabal, Claudia L., Vasan, Ramachandran S., Yaqub, Amber, Debette, Stephanie, Dufouil, Carole, Launer, Lenore J., Kremen, William S., Longstreth, William T., Ikram, M Arfan, Seshadri, Sudha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993877/
https://www.ncbi.nlm.nih.gov/pubmed/35396452
http://dx.doi.org/10.1038/s42003-022-03287-y

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