Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling

The cytokine IFNγ differentially impacts on tumors upon immune checkpoint blockade (ICB). Despite our understanding of downstream signaling events, less is known about regulation of its receptor (IFNγ-R1). With an unbiased genome-wide CRISPR/Cas9 screen for critical regulators of IFNγ-R1 cell surfac...

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Detalles Bibliográficos
Autores principales: Apriamashvili, Georgi, Vredevoogd, David W., Krijgsman, Oscar, Bleijerveld, Onno B., Ligtenberg, Maarten A., de Bruijn, Beaunelle, Boshuizen, Julia, Traets, Joleen J. H., D’Empaire Altimari, Daniela, van Vliet, Alex, Lin, Chun-Pu, Visser, Nils L., Londino, James D., Sanchez-Hodge, Rebekah, Oswalt, Leah E., Altinok, Selin, Schisler, Jonathan C., Altelaar, Maarten, Peeper, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993893/
https://www.ncbi.nlm.nih.gov/pubmed/35395848
http://dx.doi.org/10.1038/s41467-022-29442-x

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