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Eccrine Hidradenocarcinoma of the Scalp

Eccrine hidradenocarcinoma is a rare adnexal neoplasm arising from the eccrine sweat glands of the skin. Surgery and radiotherapy are the mainstay of treatment, and chemotherapy is reserved for unresectable or metastatic lesions. We present the case of a 60-year-old man, referred for treatment of an...

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Autores principales: Martins, Diana, Pereira, Filipa, Azevedo, Rosa, Julião, Ivo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994172/
https://www.ncbi.nlm.nih.gov/pubmed/35419234
http://dx.doi.org/10.7759/cureus.23023
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author Martins, Diana
Pereira, Filipa
Azevedo, Rosa
Julião, Ivo
author_facet Martins, Diana
Pereira, Filipa
Azevedo, Rosa
Julião, Ivo
author_sort Martins, Diana
collection PubMed
description Eccrine hidradenocarcinoma is a rare adnexal neoplasm arising from the eccrine sweat glands of the skin. Surgery and radiotherapy are the mainstay of treatment, and chemotherapy is reserved for unresectable or metastatic lesions. We present the case of a 60-year-old man, referred for treatment of an unresectable basal cell carcinoma of the scalp. He started Vismodegib in January of 2017 but progressed after three months. A new biopsy showed a poorly differentiated carcinoma. The patient started carboplatin/paclitaxel with a major response, enabling surgery in December of 2017. Pathology concluded on a hidradenocarcinoma, R1, and radiotherapy was not possible due to local infection. Four months later, he underwent radiotherapy due to local recurrence, and restarted carboplatin/paclitaxel, but with progressive disease. An exploratory surgery in October of 2018 revealed unresectable disease. Restaging showed lung metastasis and second-line chemotherapy was proposed. However, due to continued clinical deterioration, the patient died in February of 2019.
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spelling pubmed-89941722022-04-12 Eccrine Hidradenocarcinoma of the Scalp Martins, Diana Pereira, Filipa Azevedo, Rosa Julião, Ivo Cureus Dermatology Eccrine hidradenocarcinoma is a rare adnexal neoplasm arising from the eccrine sweat glands of the skin. Surgery and radiotherapy are the mainstay of treatment, and chemotherapy is reserved for unresectable or metastatic lesions. We present the case of a 60-year-old man, referred for treatment of an unresectable basal cell carcinoma of the scalp. He started Vismodegib in January of 2017 but progressed after three months. A new biopsy showed a poorly differentiated carcinoma. The patient started carboplatin/paclitaxel with a major response, enabling surgery in December of 2017. Pathology concluded on a hidradenocarcinoma, R1, and radiotherapy was not possible due to local infection. Four months later, he underwent radiotherapy due to local recurrence, and restarted carboplatin/paclitaxel, but with progressive disease. An exploratory surgery in October of 2018 revealed unresectable disease. Restaging showed lung metastasis and second-line chemotherapy was proposed. However, due to continued clinical deterioration, the patient died in February of 2019. Cureus 2022-03-10 /pmc/articles/PMC8994172/ /pubmed/35419234 http://dx.doi.org/10.7759/cureus.23023 Text en Copyright © 2022, Martins et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dermatology
Martins, Diana
Pereira, Filipa
Azevedo, Rosa
Julião, Ivo
Eccrine Hidradenocarcinoma of the Scalp
title Eccrine Hidradenocarcinoma of the Scalp
title_full Eccrine Hidradenocarcinoma of the Scalp
title_fullStr Eccrine Hidradenocarcinoma of the Scalp
title_full_unstemmed Eccrine Hidradenocarcinoma of the Scalp
title_short Eccrine Hidradenocarcinoma of the Scalp
title_sort eccrine hidradenocarcinoma of the scalp
topic Dermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994172/
https://www.ncbi.nlm.nih.gov/pubmed/35419234
http://dx.doi.org/10.7759/cureus.23023
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