A tumor suppressor role for EZH2 in diffuse midline glioma pathogenesis

Pediatric high-grade gliomas, specifically diffuse midline gliomas, account for only 20% of clinical cases but are 100% fatal. A majority of the DMG cases are characterized by the signature K27M mutation in histone H3. The H3K27M mutation opposes the function of enhancer of zeste homolog 2 (EZH2), t...

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Detalles Bibliográficos
Autores principales: Dhar, Swati, Gadd, Samantha, Patel, Priyam, Vaynshteyn, Jake, Raju, G. Praveen, Hashizume, Rintaro, Brat, Daniel J., Becher, Oren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994223/
https://www.ncbi.nlm.nih.gov/pubmed/35395831
http://dx.doi.org/10.1186/s40478-022-01336-5

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