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Association between 25-hydroxyvitamin D levels and COVID-19 severity

BACKGROUND AND AIMS: Despite reports on the impact of vitamin D status on coronavirus disease 2019 (COVID-19) severity, the association between low vitamin D status and severe COVID-19 remains unclear. Moreover, researchers have not determined the aforementioned association in Japanese patients. Thi...

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Autores principales: Takase, Tomoki, Tsugawa, Naoko, Sugiyama, Takayuki, Ikesue, Hiroaki, Eto, Masaaki, Hashida, Tohru, Tomii, Keisuke, Muroi, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994250/
https://www.ncbi.nlm.nih.gov/pubmed/35623823
http://dx.doi.org/10.1016/j.clnesp.2022.04.003
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author Takase, Tomoki
Tsugawa, Naoko
Sugiyama, Takayuki
Ikesue, Hiroaki
Eto, Masaaki
Hashida, Tohru
Tomii, Keisuke
Muroi, Nobuyuki
author_facet Takase, Tomoki
Tsugawa, Naoko
Sugiyama, Takayuki
Ikesue, Hiroaki
Eto, Masaaki
Hashida, Tohru
Tomii, Keisuke
Muroi, Nobuyuki
author_sort Takase, Tomoki
collection PubMed
description BACKGROUND AND AIMS: Despite reports on the impact of vitamin D status on coronavirus disease 2019 (COVID-19) severity, the association between low vitamin D status and severe COVID-19 remains unclear. Moreover, researchers have not determined the aforementioned association in Japanese patients. This study aimed to investigate the association between 25-hydroxyvitamin D [25(OH)D] levels and COVID-19 severity in Japanese patients. METHODS: This retrospective observational study included 117 consecutive patients with COVID-19 admitted to the Kobe City Medical Center General Hospital between October 01, 2020, and January 31, 2021. We measured the serum 25(OH)D levels using blood specimens collected within 5 days of hospital admission using liquid chromatography-tandem mass spectrometry. RESULTS: There were 21 (17.9%), 73 (62.4%), 19 (16.2%) and 4 (3.4%) patients with severe deficiency (<10 ng/mL), deficiency (10–<20 ng/mL), insufficiency (20–<30 ng/mL), and sufficiency (≥30 ng/mL) of vitamin D, respectively. In univariate logistic regression analyses, lower serum 25(OH)D levels [odds ratio (OR) 1.18 per 1 ng/mL decrease, 95% confidence interval (CI) 1.04–1.33, p = 0.007] were significantly associated with invasive mechanical ventilation (IMV) or death. In a multivariate logistic regression analysis, low serum 25(OH)D levels [OR 1.22 per 1 ng/mL decrease, 95% CI 1.06–1.40, p = 0.005] were significantly associated with IMV or death. The cut-off value of serum 25(OH)D levels was 10.4 ng/mL, calculated by the receiver operating characteristic curve to detect the requirement for IMV or death. CONCLUSIONS: To the best of our knowledge, this is the first study to assess the association between vitamin D status and COVID-19 severity in Japanese patients. Low serum 25(OH)D level was detected as an independent risk factor for severe COVID-19 among Japanese patients.
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spelling pubmed-89942502022-04-11 Association between 25-hydroxyvitamin D levels and COVID-19 severity Takase, Tomoki Tsugawa, Naoko Sugiyama, Takayuki Ikesue, Hiroaki Eto, Masaaki Hashida, Tohru Tomii, Keisuke Muroi, Nobuyuki Clin Nutr ESPEN Original Article BACKGROUND AND AIMS: Despite reports on the impact of vitamin D status on coronavirus disease 2019 (COVID-19) severity, the association between low vitamin D status and severe COVID-19 remains unclear. Moreover, researchers have not determined the aforementioned association in Japanese patients. This study aimed to investigate the association between 25-hydroxyvitamin D [25(OH)D] levels and COVID-19 severity in Japanese patients. METHODS: This retrospective observational study included 117 consecutive patients with COVID-19 admitted to the Kobe City Medical Center General Hospital between October 01, 2020, and January 31, 2021. We measured the serum 25(OH)D levels using blood specimens collected within 5 days of hospital admission using liquid chromatography-tandem mass spectrometry. RESULTS: There were 21 (17.9%), 73 (62.4%), 19 (16.2%) and 4 (3.4%) patients with severe deficiency (<10 ng/mL), deficiency (10–<20 ng/mL), insufficiency (20–<30 ng/mL), and sufficiency (≥30 ng/mL) of vitamin D, respectively. In univariate logistic regression analyses, lower serum 25(OH)D levels [odds ratio (OR) 1.18 per 1 ng/mL decrease, 95% confidence interval (CI) 1.04–1.33, p = 0.007] were significantly associated with invasive mechanical ventilation (IMV) or death. In a multivariate logistic regression analysis, low serum 25(OH)D levels [OR 1.22 per 1 ng/mL decrease, 95% CI 1.06–1.40, p = 0.005] were significantly associated with IMV or death. The cut-off value of serum 25(OH)D levels was 10.4 ng/mL, calculated by the receiver operating characteristic curve to detect the requirement for IMV or death. CONCLUSIONS: To the best of our knowledge, this is the first study to assess the association between vitamin D status and COVID-19 severity in Japanese patients. Low serum 25(OH)D level was detected as an independent risk factor for severe COVID-19 among Japanese patients. The Author(s). Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. 2022-06 2022-04-09 /pmc/articles/PMC8994250/ /pubmed/35623823 http://dx.doi.org/10.1016/j.clnesp.2022.04.003 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Takase, Tomoki
Tsugawa, Naoko
Sugiyama, Takayuki
Ikesue, Hiroaki
Eto, Masaaki
Hashida, Tohru
Tomii, Keisuke
Muroi, Nobuyuki
Association between 25-hydroxyvitamin D levels and COVID-19 severity
title Association between 25-hydroxyvitamin D levels and COVID-19 severity
title_full Association between 25-hydroxyvitamin D levels and COVID-19 severity
title_fullStr Association between 25-hydroxyvitamin D levels and COVID-19 severity
title_full_unstemmed Association between 25-hydroxyvitamin D levels and COVID-19 severity
title_short Association between 25-hydroxyvitamin D levels and COVID-19 severity
title_sort association between 25-hydroxyvitamin d levels and covid-19 severity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994250/
https://www.ncbi.nlm.nih.gov/pubmed/35623823
http://dx.doi.org/10.1016/j.clnesp.2022.04.003
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