Discovery of a new generation of angiotensin receptor blocking drugs: Receptor mechanisms and in silico binding to enzymes relevant to SARS-CoV-2

The discovery and facile synthesis of a new class of sartan-like arterial antihypertensive drugs (angiotensin receptor blockers [ARBs]), subsequently referred to as “bisartans” is reported. In vivo results and complementary molecular modelling presented in this communication indicate bisartans may b...

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Detalles Bibliográficos
Autores principales: Ridgway, Harry, Moore, Graham J., Mavromoustakos, Thomas, Tsiodras, Sotirios, Ligielli, Irene, Kelaidonis, Konstantinos, Chasapis, Christos T., Gadanec, Laura Kate, Zulli, Anthony, Apostolopoulos, Vasso, Petty, Russell, Karakasiliotis, Ioannis, Gorgoulis, Vassilis G., Matsoukas, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994259/
https://www.ncbi.nlm.nih.gov/pubmed/35432786
http://dx.doi.org/10.1016/j.csbj.2022.04.010

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