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Association of acute hepatitis B and acute myopathy: a case report

BACKGROUND: Hepatitis B virus infection is a global public health problem. Although hepatitis B virus primarily affects hepatocytes, it sometimes develops disease manifestations outside the liver, such as myopathy, which is commonly caused by chronic hepatitis B. CASE PRESENTATION: This case report...

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Autores principales: Zangeneh, Mehrangiz, Mesgarian, Masoomeh, Khosravani-Nezhad, Yasamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994323/
https://www.ncbi.nlm.nih.gov/pubmed/35395817
http://dx.doi.org/10.1186/s13256-022-03330-w
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author Zangeneh, Mehrangiz
Mesgarian, Masoomeh
Khosravani-Nezhad, Yasamin
author_facet Zangeneh, Mehrangiz
Mesgarian, Masoomeh
Khosravani-Nezhad, Yasamin
author_sort Zangeneh, Mehrangiz
collection PubMed
description BACKGROUND: Hepatitis B virus infection is a global public health problem. Although hepatitis B virus primarily affects hepatocytes, it sometimes develops disease manifestations outside the liver, such as myopathy, which is commonly caused by chronic hepatitis B. CASE PRESENTATION: This case report describes a 57-year-old Iranian woman admitted to the hospital with jaundice, fever, body itching, abdominal pain, progressive muscle weakness, icteric sclera, right upper quadrant pain, and decreased muscle force. Examination on the first day of admission revealed that the patient was negative for hepatitis D antibody, positive for hepatitis B core (IgM) antibody, positive for hepatitis B surface antigen, and negative for hepatitis B e antibody but positive for hepatitis B e antigen. Moreover, she showed high levels of hepatitis B virus DNA viral load, creatine kinase, lactate dehydrogenase, serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminase, total bilirubin, direct bilirubin, and alkaline phosphatase, and electromyography/nerve conduction velocity showed acute myopathic process. CONCLUSIONS: Interestingly, myopathy symptoms improved after improving hepatitis symptoms and decreasing hepatitis B viral load, suggesting a close association between hepatitis B infection and myopathy.
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spelling pubmed-89943232022-04-10 Association of acute hepatitis B and acute myopathy: a case report Zangeneh, Mehrangiz Mesgarian, Masoomeh Khosravani-Nezhad, Yasamin J Med Case Rep Case Report BACKGROUND: Hepatitis B virus infection is a global public health problem. Although hepatitis B virus primarily affects hepatocytes, it sometimes develops disease manifestations outside the liver, such as myopathy, which is commonly caused by chronic hepatitis B. CASE PRESENTATION: This case report describes a 57-year-old Iranian woman admitted to the hospital with jaundice, fever, body itching, abdominal pain, progressive muscle weakness, icteric sclera, right upper quadrant pain, and decreased muscle force. Examination on the first day of admission revealed that the patient was negative for hepatitis D antibody, positive for hepatitis B core (IgM) antibody, positive for hepatitis B surface antigen, and negative for hepatitis B e antibody but positive for hepatitis B e antigen. Moreover, she showed high levels of hepatitis B virus DNA viral load, creatine kinase, lactate dehydrogenase, serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminase, total bilirubin, direct bilirubin, and alkaline phosphatase, and electromyography/nerve conduction velocity showed acute myopathic process. CONCLUSIONS: Interestingly, myopathy symptoms improved after improving hepatitis symptoms and decreasing hepatitis B viral load, suggesting a close association between hepatitis B infection and myopathy. BioMed Central 2022-04-09 /pmc/articles/PMC8994323/ /pubmed/35395817 http://dx.doi.org/10.1186/s13256-022-03330-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Zangeneh, Mehrangiz
Mesgarian, Masoomeh
Khosravani-Nezhad, Yasamin
Association of acute hepatitis B and acute myopathy: a case report
title Association of acute hepatitis B and acute myopathy: a case report
title_full Association of acute hepatitis B and acute myopathy: a case report
title_fullStr Association of acute hepatitis B and acute myopathy: a case report
title_full_unstemmed Association of acute hepatitis B and acute myopathy: a case report
title_short Association of acute hepatitis B and acute myopathy: a case report
title_sort association of acute hepatitis b and acute myopathy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994323/
https://www.ncbi.nlm.nih.gov/pubmed/35395817
http://dx.doi.org/10.1186/s13256-022-03330-w
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