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Clinical Characteristics of Patients with Hepatocellular Carcinoma: A Single-Center 3-Year Experience from Somalia

BACKGROUND: To evaluate the relationship between prognosticators representing tumor aggressiveness and socio-demographic, laboratory, and imaging findings in patients with hepatocellular carcinoma (HCC). METHODS: We retrospectively searched patients with HCC between January 2017 and December 2019 in...

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Autores principales: Hassan-Kadle, Mohamed A., Osman, Marian Muse, Keles, Esra, Eker, Hasan Huseyin, Baydili, Kursad Nuri, Ahmed, Hussein Mahdi, Osman, Abdirahman Abdikadir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994688/
https://www.ncbi.nlm.nih.gov/pubmed/35411218
http://dx.doi.org/10.1155/2022/3370992
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author Hassan-Kadle, Mohamed A.
Osman, Marian Muse
Keles, Esra
Eker, Hasan Huseyin
Baydili, Kursad Nuri
Ahmed, Hussein Mahdi
Osman, Abdirahman Abdikadir
author_facet Hassan-Kadle, Mohamed A.
Osman, Marian Muse
Keles, Esra
Eker, Hasan Huseyin
Baydili, Kursad Nuri
Ahmed, Hussein Mahdi
Osman, Abdirahman Abdikadir
author_sort Hassan-Kadle, Mohamed A.
collection PubMed
description BACKGROUND: To evaluate the relationship between prognosticators representing tumor aggressiveness and socio-demographic, laboratory, and imaging findings in patients with hepatocellular carcinoma (HCC). METHODS: We retrospectively searched patients with HCC between January 2017 and December 2019 in our tertiary referral hospital. The tumor-related factors and liver damage indicators and their relationship to indicate the value of prognosis were analyzed. RESULTS: A total of 268 HCC patients, with a male-to-female ratio of 2.8 : 1. The mean age was 52.6 years. The patient with portal vein thrombosis (PVT) was older, had higher liver laboratory parameters (AST, ALT, total bilirubin, and direct bilirubin), and had larger tumor size. Patients with the larger tumor size had a higher AFP level, had more tumor multifocality. The majority of patients were in Child's A (73.6%) and B (17.2%) classes. The laboratory parameters of HCC patients were increased in Child's C compared to other groups of Child-Pugh classification. CONCLUSIONS: The presence of PVT and large-sized tumor in patients with HCC indicated a poorer prognosis than non-PVT group and small tumor sizes.
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spelling pubmed-89946882022-04-10 Clinical Characteristics of Patients with Hepatocellular Carcinoma: A Single-Center 3-Year Experience from Somalia Hassan-Kadle, Mohamed A. Osman, Marian Muse Keles, Esra Eker, Hasan Huseyin Baydili, Kursad Nuri Ahmed, Hussein Mahdi Osman, Abdirahman Abdikadir Int J Hepatol Research Article BACKGROUND: To evaluate the relationship between prognosticators representing tumor aggressiveness and socio-demographic, laboratory, and imaging findings in patients with hepatocellular carcinoma (HCC). METHODS: We retrospectively searched patients with HCC between January 2017 and December 2019 in our tertiary referral hospital. The tumor-related factors and liver damage indicators and their relationship to indicate the value of prognosis were analyzed. RESULTS: A total of 268 HCC patients, with a male-to-female ratio of 2.8 : 1. The mean age was 52.6 years. The patient with portal vein thrombosis (PVT) was older, had higher liver laboratory parameters (AST, ALT, total bilirubin, and direct bilirubin), and had larger tumor size. Patients with the larger tumor size had a higher AFP level, had more tumor multifocality. The majority of patients were in Child's A (73.6%) and B (17.2%) classes. The laboratory parameters of HCC patients were increased in Child's C compared to other groups of Child-Pugh classification. CONCLUSIONS: The presence of PVT and large-sized tumor in patients with HCC indicated a poorer prognosis than non-PVT group and small tumor sizes. Hindawi 2022-04-02 /pmc/articles/PMC8994688/ /pubmed/35411218 http://dx.doi.org/10.1155/2022/3370992 Text en Copyright © 2022 Mohamed A. Hassan-Kadle et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hassan-Kadle, Mohamed A.
Osman, Marian Muse
Keles, Esra
Eker, Hasan Huseyin
Baydili, Kursad Nuri
Ahmed, Hussein Mahdi
Osman, Abdirahman Abdikadir
Clinical Characteristics of Patients with Hepatocellular Carcinoma: A Single-Center 3-Year Experience from Somalia
title Clinical Characteristics of Patients with Hepatocellular Carcinoma: A Single-Center 3-Year Experience from Somalia
title_full Clinical Characteristics of Patients with Hepatocellular Carcinoma: A Single-Center 3-Year Experience from Somalia
title_fullStr Clinical Characteristics of Patients with Hepatocellular Carcinoma: A Single-Center 3-Year Experience from Somalia
title_full_unstemmed Clinical Characteristics of Patients with Hepatocellular Carcinoma: A Single-Center 3-Year Experience from Somalia
title_short Clinical Characteristics of Patients with Hepatocellular Carcinoma: A Single-Center 3-Year Experience from Somalia
title_sort clinical characteristics of patients with hepatocellular carcinoma: a single-center 3-year experience from somalia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994688/
https://www.ncbi.nlm.nih.gov/pubmed/35411218
http://dx.doi.org/10.1155/2022/3370992
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