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Hyperinflammation Reduces Midazolam Metabolism in Critically Ill Adults with COVID-19

BACKGROUND AND OBJECTIVE: Many patients treated for COVID-19 related acute respiratory distress syndrome in the intensive care unit are sedated with the benzodiazepine midazolam. Midazolam undergoes extensive metabolism by CYP3A enzymes, which may be inhibited by hyperinflammation. Therefore, an exa...

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Detalles Bibliográficos
Autores principales:	Smeets, Tim J. L., Valkenburg, Abraham J., van der Jagt, Mathieu, Koch, Birgit C. P., Endeman, Henrik, Gommers, Diederik A. M. P. J., Sassen, Sebastian D. T., Hunfeld, Nicole G. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994846/ https://www.ncbi.nlm.nih.gov/pubmed/35397768 http://dx.doi.org/10.1007/s40262-022-01122-5

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