Impulsivity is associated with firing regularity in parkinsonian ventral subthalamic nucleus

Impulsive–compulsive behaviors (ICB) are over‐represented in Parkinson's disease (PD) patients. Neurons in the ventral subthalamic nucleus (STN) might play a predominant role in the modulation of impulsivity. We characterized the firing regularity of 742 subthalamic neurons from 24 PD patients...

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Autores principales: Vissani, Matteo, Micheli, Federico, Pecchioli, Guido, Ramat, Silvia, Mazzoni, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2022
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994976/
https://www.ncbi.nlm.nih.gov/pubmed/35233976
http://dx.doi.org/10.1002/acn3.51530
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author Vissani, Matteo
Micheli, Federico
Pecchioli, Guido
Ramat, Silvia
Mazzoni, Alberto
author_facet Vissani, Matteo
Micheli, Federico
Pecchioli, Guido
Ramat, Silvia
Mazzoni, Alberto
author_sort Vissani, Matteo
collection PubMed
description Impulsive–compulsive behaviors (ICB) are over‐represented in Parkinson's disease (PD) patients. Neurons in the ventral subthalamic nucleus (STN) might play a predominant role in the modulation of impulsivity. We characterized the firing regularity of 742 subthalamic neurons from 24 PD patients (12 ICB+ and 12 ICB‐) in an OFF medication state. We computed the firing regularity in the dorsal and ventral STN regions, and we compared their performance in discriminating ICB patients. Regularity of ventral neurons in ICB+ patients is higher and supports a significant discrimination between the two cohorts. These results substantiate a ventral location of neurons involved in impulsivity.
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spelling pubmed-89949762022-04-15 Impulsivity is associated with firing regularity in parkinsonian ventral subthalamic nucleus Vissani, Matteo Micheli, Federico Pecchioli, Guido Ramat, Silvia Mazzoni, Alberto Ann Clin Transl Neurol Brief Communications Impulsive–compulsive behaviors (ICB) are over‐represented in Parkinson's disease (PD) patients. Neurons in the ventral subthalamic nucleus (STN) might play a predominant role in the modulation of impulsivity. We characterized the firing regularity of 742 subthalamic neurons from 24 PD patients (12 ICB+ and 12 ICB‐) in an OFF medication state. We computed the firing regularity in the dorsal and ventral STN regions, and we compared their performance in discriminating ICB patients. Regularity of ventral neurons in ICB+ patients is higher and supports a significant discrimination between the two cohorts. These results substantiate a ventral location of neurons involved in impulsivity. Blackwell Publishing Ltd 2022-03-02 /pmc/articles/PMC8994976/ /pubmed/35233976 http://dx.doi.org/10.1002/acn3.51530 Text en © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Vissani, Matteo
Micheli, Federico
Pecchioli, Guido
Ramat, Silvia
Mazzoni, Alberto
Impulsivity is associated with firing regularity in parkinsonian ventral subthalamic nucleus
title Impulsivity is associated with firing regularity in parkinsonian ventral subthalamic nucleus
title_full Impulsivity is associated with firing regularity in parkinsonian ventral subthalamic nucleus
title_fullStr Impulsivity is associated with firing regularity in parkinsonian ventral subthalamic nucleus
title_full_unstemmed Impulsivity is associated with firing regularity in parkinsonian ventral subthalamic nucleus
title_short Impulsivity is associated with firing regularity in parkinsonian ventral subthalamic nucleus
title_sort impulsivity is associated with firing regularity in parkinsonian ventral subthalamic nucleus
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994976/
https://www.ncbi.nlm.nih.gov/pubmed/35233976
http://dx.doi.org/10.1002/acn3.51530
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