Acute epileptiform abnormalities are the primary predictors of post‐stroke epilepsy: a matched, case–control study

Stroke patients who underwent continuous EEG (cEEG) monitoring within 7 days of presentation and developed post‐stroke epilepsy (PSE; cases, n = 36) were matched (1:2 ratio) by age and follow‐up duration with ones who did not (controls, n = 72). Variables significant on univariable analysis [hyperte...

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Autores principales: Punia, Vineet, Ellison, Lisa, Bena, Jim, Chandan, Pradeep, Sivaraju, Adithya, George, Pravin, Newey, Christopher R., Hantus, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2022
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994977/
https://www.ncbi.nlm.nih.gov/pubmed/35243824
http://dx.doi.org/10.1002/acn3.51534
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author Punia, Vineet
Ellison, Lisa
Bena, Jim
Chandan, Pradeep
Sivaraju, Adithya
George, Pravin
Newey, Christopher R.
Hantus, Stephen
author_facet Punia, Vineet
Ellison, Lisa
Bena, Jim
Chandan, Pradeep
Sivaraju, Adithya
George, Pravin
Newey, Christopher R.
Hantus, Stephen
author_sort Punia, Vineet
collection PubMed
description Stroke patients who underwent continuous EEG (cEEG) monitoring within 7 days of presentation and developed post‐stroke epilepsy (PSE; cases, n = 36) were matched (1:2 ratio) by age and follow‐up duration with ones who did not (controls, n = 72). Variables significant on univariable analysis [hypertension, smoking, hemorrhagic conversion, pre‐cEEG convulsive seizures, and epileptiform abnormalities (EAs)] were included in the multivariable logistic model and only the presence of EAs on EEG remained significant PSE predictor [OR = 11.9 (1.75–491.6)]. With acute EAs independently predicting PSE development, accounting for their presence may help to tailor post‐acute symptomatic seizure management and aid anti‐epileptogenesis therapy trials.
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spelling pubmed-89949772022-04-15 Acute epileptiform abnormalities are the primary predictors of post‐stroke epilepsy: a matched, case–control study Punia, Vineet Ellison, Lisa Bena, Jim Chandan, Pradeep Sivaraju, Adithya George, Pravin Newey, Christopher R. Hantus, Stephen Ann Clin Transl Neurol Brief Communications Stroke patients who underwent continuous EEG (cEEG) monitoring within 7 days of presentation and developed post‐stroke epilepsy (PSE; cases, n = 36) were matched (1:2 ratio) by age and follow‐up duration with ones who did not (controls, n = 72). Variables significant on univariable analysis [hypertension, smoking, hemorrhagic conversion, pre‐cEEG convulsive seizures, and epileptiform abnormalities (EAs)] were included in the multivariable logistic model and only the presence of EAs on EEG remained significant PSE predictor [OR = 11.9 (1.75–491.6)]. With acute EAs independently predicting PSE development, accounting for their presence may help to tailor post‐acute symptomatic seizure management and aid anti‐epileptogenesis therapy trials. Blackwell Publishing Ltd 2022-03-03 /pmc/articles/PMC8994977/ /pubmed/35243824 http://dx.doi.org/10.1002/acn3.51534 Text en © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Punia, Vineet
Ellison, Lisa
Bena, Jim
Chandan, Pradeep
Sivaraju, Adithya
George, Pravin
Newey, Christopher R.
Hantus, Stephen
Acute epileptiform abnormalities are the primary predictors of post‐stroke epilepsy: a matched, case–control study
title Acute epileptiform abnormalities are the primary predictors of post‐stroke epilepsy: a matched, case–control study
title_full Acute epileptiform abnormalities are the primary predictors of post‐stroke epilepsy: a matched, case–control study
title_fullStr Acute epileptiform abnormalities are the primary predictors of post‐stroke epilepsy: a matched, case–control study
title_full_unstemmed Acute epileptiform abnormalities are the primary predictors of post‐stroke epilepsy: a matched, case–control study
title_short Acute epileptiform abnormalities are the primary predictors of post‐stroke epilepsy: a matched, case–control study
title_sort acute epileptiform abnormalities are the primary predictors of post‐stroke epilepsy: a matched, case–control study
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994977/
https://www.ncbi.nlm.nih.gov/pubmed/35243824
http://dx.doi.org/10.1002/acn3.51534
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