Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa

Here, we provide two methods for monitoring reinfection trends in routine surveillance data to identify signatures of changes in reinfection risk and apply these approaches to data from South Africa’s SARS-CoV-2 epidemic to date. While we found no evidence of increased reinfection risk associated wi...

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Detalles Bibliográficos
Autores principales: Pulliam, Juliet R. C., van Schalkwyk, Cari, Govender, Nevashan, von Gottberg, Anne, Cohen, Cheryl, Groome, Michelle J., Dushoff, Jonathan, Mlisana, Koleka, Moultrie, Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995029/
https://www.ncbi.nlm.nih.gov/pubmed/35289632
http://dx.doi.org/10.1126/science.abn4947
Descripción
Sumario:Here, we provide two methods for monitoring reinfection trends in routine surveillance data to identify signatures of changes in reinfection risk and apply these approaches to data from South Africa’s SARS-CoV-2 epidemic to date. While we found no evidence of increased reinfection risk associated with circulation of Beta (B.1.351) or Delta (B.1.617.2) variants, we find clear, population-level evidence to suggest immune evasion by the Omicron (B.1.1.529) variant in previously infected individuals in South Africa. Reinfections occurring between 01 November 2021 and 31 January 2022 were detected in individuals infected in all three previous waves, and there has been an increase in the risk of having a third infection since mid-November 2021.

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