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mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions
The successful development of several coronavirus disease 2019 (COVID-19) vaccines has substantially reduced morbidity and mortality in regions of the world where the vaccines have been deployed. However, in the wake of the emergence of viral variants that are able to evade vaccine-induced neutraliz...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995030/ https://www.ncbi.nlm.nih.gov/pubmed/35348368 http://dx.doi.org/10.1126/scitranslmed.abm2311 |
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author | Kaplonek, Paulina Cizmeci, Deniz Fischinger, Stephanie Collier, Ai-ris Suscovich, Todd Linde, Caitlyn Broge, Thomas Mann, Colin Amanat, Fatima Dayal, Diana Rhee, Justin de St. Aubin, Michael Nilles, Eric J. Musk, Elon R. Menon, Anil S. Saphire, Erica Ollmann Krammer, Florian Lauffenburger, Douglas A. Barouch, Dan H. Alter, Galit |
author_facet | Kaplonek, Paulina Cizmeci, Deniz Fischinger, Stephanie Collier, Ai-ris Suscovich, Todd Linde, Caitlyn Broge, Thomas Mann, Colin Amanat, Fatima Dayal, Diana Rhee, Justin de St. Aubin, Michael Nilles, Eric J. Musk, Elon R. Menon, Anil S. Saphire, Erica Ollmann Krammer, Florian Lauffenburger, Douglas A. Barouch, Dan H. Alter, Galit |
author_sort | Kaplonek, Paulina |
collection | PubMed |
description | The successful development of several coronavirus disease 2019 (COVID-19) vaccines has substantially reduced morbidity and mortality in regions of the world where the vaccines have been deployed. However, in the wake of the emergence of viral variants that are able to evade vaccine-induced neutralizing antibodies, real-world vaccine efficacy has begun to show differences across the two approved mRNA platforms, BNT162b2 and mRNA-1273; these findings suggest that subtle variation in immune responses induced by the BNT162b2 and mRNA-1273 vaccines may confer differential protection. Given our emerging appreciation for the importance of additional antibody functions beyond neutralization, we profiled the post-boost binding and functional capacity of humoral immune responses induced by the BNT162b2 and mRNA-1273 vaccines in a cohort of hospital staff. Both vaccines induced robust humoral immune responses to wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to variants of concern. However, differences emerged across epitope-specific responses, with higher concentrations of receptor binding domain (RBD)- and N-terminal domain-specific IgA observed in recipients of mRNA-1273. Antibodies eliciting neutrophil phagocytosis and natural killer cell activation were also increased in mRNA-1273 vaccine recipients as compared to BNT162b2 recipients. RBD-specific antibody depletion highlighted the different roles of non-RBD-specific antibody effector functions induced across the mRNA vaccines. These data provide insights into potential differences in protective immunity conferred by these vaccines. |
format | Online Article Text |
id | pubmed-8995030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-89950302022-04-12 mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions Kaplonek, Paulina Cizmeci, Deniz Fischinger, Stephanie Collier, Ai-ris Suscovich, Todd Linde, Caitlyn Broge, Thomas Mann, Colin Amanat, Fatima Dayal, Diana Rhee, Justin de St. Aubin, Michael Nilles, Eric J. Musk, Elon R. Menon, Anil S. Saphire, Erica Ollmann Krammer, Florian Lauffenburger, Douglas A. Barouch, Dan H. Alter, Galit Sci Transl Med Research Articles The successful development of several coronavirus disease 2019 (COVID-19) vaccines has substantially reduced morbidity and mortality in regions of the world where the vaccines have been deployed. However, in the wake of the emergence of viral variants that are able to evade vaccine-induced neutralizing antibodies, real-world vaccine efficacy has begun to show differences across the two approved mRNA platforms, BNT162b2 and mRNA-1273; these findings suggest that subtle variation in immune responses induced by the BNT162b2 and mRNA-1273 vaccines may confer differential protection. Given our emerging appreciation for the importance of additional antibody functions beyond neutralization, we profiled the post-boost binding and functional capacity of humoral immune responses induced by the BNT162b2 and mRNA-1273 vaccines in a cohort of hospital staff. Both vaccines induced robust humoral immune responses to wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to variants of concern. However, differences emerged across epitope-specific responses, with higher concentrations of receptor binding domain (RBD)- and N-terminal domain-specific IgA observed in recipients of mRNA-1273. Antibodies eliciting neutrophil phagocytosis and natural killer cell activation were also increased in mRNA-1273 vaccine recipients as compared to BNT162b2 recipients. RBD-specific antibody depletion highlighted the different roles of non-RBD-specific antibody effector functions induced across the mRNA vaccines. These data provide insights into potential differences in protective immunity conferred by these vaccines. American Association for the Advancement of Science 2022-03-29 /pmc/articles/PMC8995030/ /pubmed/35348368 http://dx.doi.org/10.1126/scitranslmed.abm2311 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Kaplonek, Paulina Cizmeci, Deniz Fischinger, Stephanie Collier, Ai-ris Suscovich, Todd Linde, Caitlyn Broge, Thomas Mann, Colin Amanat, Fatima Dayal, Diana Rhee, Justin de St. Aubin, Michael Nilles, Eric J. Musk, Elon R. Menon, Anil S. Saphire, Erica Ollmann Krammer, Florian Lauffenburger, Douglas A. Barouch, Dan H. Alter, Galit mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions |
title | mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions |
title_full | mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions |
title_fullStr | mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions |
title_full_unstemmed | mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions |
title_short | mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions |
title_sort | mrna-1273 and bnt162b2 covid-19 vaccines elicit antibodies with differences in fc-mediated effector functions |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995030/ https://www.ncbi.nlm.nih.gov/pubmed/35348368 http://dx.doi.org/10.1126/scitranslmed.abm2311 |
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