KIR(+)CD8(+) T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19

In this work, we find that CD8(+) T cells expressing inhibitory killer cell immunoglobulin-like receptors (KIRs) are the human equivalent of Ly49(+)CD8(+) regulatory T cells in mice and are increased in the blood and inflamed tissues of patients with a variety of autoimmune diseases. Moreover, these...

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Detalles Bibliográficos
Autores principales: Li, Jing, Zaslavsky, Maxim, Su, Yapeng, Guo, Jing, Sikora, Michael J., van Unen, Vincent, Christophersen, Asbjørn, Chiou, Shin-Heng, Chen, Liang, Li, Jiefu, Ji, Xuhuai, Wilhelmy, Julie, McSween, Alana M., Palanski, Brad A., Mallajosyula, Venkata Vamsee Aditya, Bracey, Nathan A., Dhondalay, Gopal Krishna R., Bhamidipati, Kartik, Pai, Joy, Kipp, Lucas B., Dunn, Jeffrey E., Hauser, Stephen L., Oksenberg, Jorge R., Satpathy, Ansuman T., Robinson, William H., Dekker, Cornelia L., Steinmetz, Lars M., Khosla, Chaitan, Utz, Paul J., Sollid, Ludvig M., Chien, Yueh-Hsiu, Heath, James R., Fernandez-Becker, Nielsen Q., Nadeau, Kari C., Saligrama, Naresha, Davis, Mark M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995031/
https://www.ncbi.nlm.nih.gov/pubmed/35258337
http://dx.doi.org/10.1126/science.abi9591

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