A modified vaccinia Ankara vaccine expressing spike and nucleocapsid protects rhesus macaques against SARS-CoV-2 delta infection

SARS-CoV-2 vaccines should induce broadly cross-reactive humoral and T cell responses to protect against emerging variants of concern (VOCs). Here, we inactivated the furin-cleavage site (FCS) of spike expressed by a modified vaccinia Ankara (MVA) virus vaccine (MVA/SdFCS) and found that FCS inactiv...

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Detalles Bibliográficos
Autores principales: Routhu, Nanda Kishore, Gangadhara, Sailaja, Lai, Lilin, Davis Gardner, Meredith Elizabeth, Floyd, Katharine, Shiferaw, Ayalnesh, Bartsch, Yannic C, Fischinger, Stephanie, Khoury, Georges, Rahman, Sheikh Abdul, Stampfer, Samuel David, Schaefer, Alexandra, Jean, Sherrie M., Wallace, Chelsea, Stammen, Rachelle L., Wood, Jennifer, Cohen, Joyce, Nagy, Tamas, Parsons, Matthew S., Gralinski, Lisa, Kozlowski, Pamela A., Alter, Galit, Suthar, Mehul S., Amara, Rama Rao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995033/
https://www.ncbi.nlm.nih.gov/pubmed/35357886
http://dx.doi.org/10.1126/sciimmunol.abo0226

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