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What Is the Optimal Follow-up Length for Mortality in Staphylococcus aureus Bacteremia? Observations From a Systematic Review of Attributable Mortality

BACKGROUND: Deaths following Staphylococcus aureus bacteremia (SAB) may be related or unrelated to the infection. In SAB therapeutics research, the length of follow-up should be optimized to capture most attributable deaths and minimize nonattributable deaths. We performed a secondary analysis of a...

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Autores principales: Bai, Anthony D, Lo, Carson K L, Komorowski, Adam S, Suresh, Mallika, Guo, Kevin, Garg, Akhil, Tandon, Pranav, Senecal, Julien, Del Corpo, Olivier, Stefanova, Isabella, Fogarty, Clare, Butler-Laporte, Guillaume, McDonald, Emily G, Cheng, Matthew P, Morris, Andrew M, Loeb, Mark, Lee, Todd C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995072/
https://www.ncbi.nlm.nih.gov/pubmed/35415199
http://dx.doi.org/10.1093/ofid/ofac096
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author Bai, Anthony D
Lo, Carson K L
Komorowski, Adam S
Suresh, Mallika
Guo, Kevin
Garg, Akhil
Tandon, Pranav
Senecal, Julien
Del Corpo, Olivier
Stefanova, Isabella
Fogarty, Clare
Butler-Laporte, Guillaume
McDonald, Emily G
Cheng, Matthew P
Morris, Andrew M
Loeb, Mark
Lee, Todd C
author_facet Bai, Anthony D
Lo, Carson K L
Komorowski, Adam S
Suresh, Mallika
Guo, Kevin
Garg, Akhil
Tandon, Pranav
Senecal, Julien
Del Corpo, Olivier
Stefanova, Isabella
Fogarty, Clare
Butler-Laporte, Guillaume
McDonald, Emily G
Cheng, Matthew P
Morris, Andrew M
Loeb, Mark
Lee, Todd C
author_sort Bai, Anthony D
collection PubMed
description BACKGROUND: Deaths following Staphylococcus aureus bacteremia (SAB) may be related or unrelated to the infection. In SAB therapeutics research, the length of follow-up should be optimized to capture most attributable deaths and minimize nonattributable deaths. We performed a secondary analysis of a systematic review to describe attributable mortality in SAB over time. METHODS: We systematically searched Medline, Embase, and Cochrane Database of Systematic Reviews from 1 January 1991 to 7 May 2021 for human observational studies of SAB. To be included in this secondary analysis, the study must have reported attributable mortality. Two reviewers extracted study data and assessed risk of bias independently. Pooling of study estimates was not performed due to heterogeneity in the definition of attributable deaths. RESULTS: Twenty-four observational cohort studies were included. The median proportion of all-cause deaths that were attributable to SAB was 77% (interquartile range [IQR], 72%–89%) at 1 month and 62% (IQR, 58%–75%) at 3 months. At 1 year, this proportion was 57% in 1 study. In 2 studies that described the rate of increase in mortality over time, 2-week follow-up captured 68 of 79 (86%) and 48 of 57 (84%) attributable deaths that occurred by 3 months. By comparison, 1-month follow-up captured 54 of 57 (95%) and 56 of 60 (93%) attributable deaths that occurred by 3 months in 2 studies. CONCLUSIONS: The proportion of deaths that are attributable to SAB decreases as follow-up lengthens. Follow-up duration between 1 and 3 months seems optimal if evaluating processes of care that impact SAB mortality. CLINICAL TRIALS REGISTRATION: PROSPERO CRD42021253891.
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spelling pubmed-89950722022-04-11 What Is the Optimal Follow-up Length for Mortality in Staphylococcus aureus Bacteremia? Observations From a Systematic Review of Attributable Mortality Bai, Anthony D Lo, Carson K L Komorowski, Adam S Suresh, Mallika Guo, Kevin Garg, Akhil Tandon, Pranav Senecal, Julien Del Corpo, Olivier Stefanova, Isabella Fogarty, Clare Butler-Laporte, Guillaume McDonald, Emily G Cheng, Matthew P Morris, Andrew M Loeb, Mark Lee, Todd C Open Forum Infect Dis Major Article BACKGROUND: Deaths following Staphylococcus aureus bacteremia (SAB) may be related or unrelated to the infection. In SAB therapeutics research, the length of follow-up should be optimized to capture most attributable deaths and minimize nonattributable deaths. We performed a secondary analysis of a systematic review to describe attributable mortality in SAB over time. METHODS: We systematically searched Medline, Embase, and Cochrane Database of Systematic Reviews from 1 January 1991 to 7 May 2021 for human observational studies of SAB. To be included in this secondary analysis, the study must have reported attributable mortality. Two reviewers extracted study data and assessed risk of bias independently. Pooling of study estimates was not performed due to heterogeneity in the definition of attributable deaths. RESULTS: Twenty-four observational cohort studies were included. The median proportion of all-cause deaths that were attributable to SAB was 77% (interquartile range [IQR], 72%–89%) at 1 month and 62% (IQR, 58%–75%) at 3 months. At 1 year, this proportion was 57% in 1 study. In 2 studies that described the rate of increase in mortality over time, 2-week follow-up captured 68 of 79 (86%) and 48 of 57 (84%) attributable deaths that occurred by 3 months. By comparison, 1-month follow-up captured 54 of 57 (95%) and 56 of 60 (93%) attributable deaths that occurred by 3 months in 2 studies. CONCLUSIONS: The proportion of deaths that are attributable to SAB decreases as follow-up lengthens. Follow-up duration between 1 and 3 months seems optimal if evaluating processes of care that impact SAB mortality. CLINICAL TRIALS REGISTRATION: PROSPERO CRD42021253891. Oxford University Press 2022-04-10 /pmc/articles/PMC8995072/ /pubmed/35415199 http://dx.doi.org/10.1093/ofid/ofac096 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Major Article
Bai, Anthony D
Lo, Carson K L
Komorowski, Adam S
Suresh, Mallika
Guo, Kevin
Garg, Akhil
Tandon, Pranav
Senecal, Julien
Del Corpo, Olivier
Stefanova, Isabella
Fogarty, Clare
Butler-Laporte, Guillaume
McDonald, Emily G
Cheng, Matthew P
Morris, Andrew M
Loeb, Mark
Lee, Todd C
What Is the Optimal Follow-up Length for Mortality in Staphylococcus aureus Bacteremia? Observations From a Systematic Review of Attributable Mortality
title What Is the Optimal Follow-up Length for Mortality in Staphylococcus aureus Bacteremia? Observations From a Systematic Review of Attributable Mortality
title_full What Is the Optimal Follow-up Length for Mortality in Staphylococcus aureus Bacteremia? Observations From a Systematic Review of Attributable Mortality
title_fullStr What Is the Optimal Follow-up Length for Mortality in Staphylococcus aureus Bacteremia? Observations From a Systematic Review of Attributable Mortality
title_full_unstemmed What Is the Optimal Follow-up Length for Mortality in Staphylococcus aureus Bacteremia? Observations From a Systematic Review of Attributable Mortality
title_short What Is the Optimal Follow-up Length for Mortality in Staphylococcus aureus Bacteremia? Observations From a Systematic Review of Attributable Mortality
title_sort what is the optimal follow-up length for mortality in staphylococcus aureus bacteremia? observations from a systematic review of attributable mortality
topic Major Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995072/
https://www.ncbi.nlm.nih.gov/pubmed/35415199
http://dx.doi.org/10.1093/ofid/ofac096
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