Neurotropic EV71 causes encephalitis by engaging intracellular TLR9 to elicit neurotoxic IL12-p40-iNOS signaling

Brainstem encephalitis, a manifestation of severe enterovirus 71 (EV71) infection, is an acute excessive inflammatory response. The mechanisms underlying its development remain poorly understood. Usually neurotropic viruses trigger acute host immune response by engaging cell surface or intracellular...

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Detalles Bibliográficos
Autores principales: Lai, Rai-Hua, Chow, Yen-Hung, Chung, Nai-Hsiang, Chen, Tsan-Chi, Shie, Feng-Shiun, Juang, Jyh-Lyh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995170/
https://www.ncbi.nlm.nih.gov/pubmed/35399111
http://dx.doi.org/10.1038/s41419-022-04771-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995170/
https://www.ncbi.nlm.nih.gov/pubmed/35399111
http://dx.doi.org/10.1038/s41419-022-04771-3

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