Cargando…

Neurotropic EV71 causes encephalitis by engaging intracellular TLR9 to elicit neurotoxic IL12-p40-iNOS signaling

Brainstem encephalitis, a manifestation of severe enterovirus 71 (EV71) infection, is an acute excessive inflammatory response. The mechanisms underlying its development remain poorly understood. Usually neurotropic viruses trigger acute host immune response by engaging cell surface or intracellular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lai, Rai-Hua, Chow, Yen-Hung, Chung, Nai-Hsiang, Chen, Tsan-Chi, Shie, Feng-Shiun, Juang, Jyh-Lyh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995170/ https://www.ncbi.nlm.nih.gov/pubmed/35399111 http://dx.doi.org/10.1038/s41419-022-04771-3

Ejemplares similares

Non‐genomic rewiring of vitamin D receptor to p53 as a key to Alzheimer's disease
por: Lai, Rai‐Hua, et al.
Publicado: (2021)

Induction of SOCS Expression by EV71 Infection Promotes EV71 Replication
por: Gao, Wenying, et al.
Publicado: (2020)

EV71 virus-like particles produced by co-expression of capsid proteins in yeast cells elicit humoral protective response against EV71 lethal challenge
por: Wang, Xiaowen, et al.
Publicado: (2016)

Obesity-Induced Coronary Microvascular Disease Is Prevented by iNOS Deletion and Reversed by iNOS Inhibition
por: Shah, Soham A., et al.
Publicado: (2023)

The dual role of iNOS in cancer()
por: Vannini, Federica, et al.
Publicado: (2015)

Plant-Produced Anti-Enterovirus 71 (EV71) Monoclonal Antibody Efficiently Protects Mice Against EV71 Infection
por: Rattanapisit, Kaewta, et al.
Publicado: (2019)

Resveratrol Protects Rats from Aβ-induced Neurotoxicity by the Reduction of iNOS Expression and Lipid Peroxidation
por: Huang, Tai-Chun, et al.
Publicado: (2011)

Differences in neurotropism and neurotoxicity among retrograde viral tracers
por: Sun, Leqiang, et al.
Publicado: (2019)

Production of EV71 vaccine candidates
por: Chong, Pele, et al.
Publicado: (2012)

Brain function in iNOS knock out or iNOS inhibited (l-NIL) mice under endotoxic shock
por: Schweighöfer, Hanna, et al.
Publicado: (2014)

A novel long intergenic non-coding RNA, Nostrill, regulates iNOS gene transcription and neurotoxicity in microglia
por: Mathy, Nicholas W., et al.
Publicado: (2021)

Inhibition of Enterovirus 71 (EV-71) Infections by a Novel Antiviral Peptide Derived from EV-71 Capsid Protein VP1
por: Tan, Chee Wah, et al.
Publicado: (2012)

The expressions of AMACR and iNOS in prostate adenocarcinomas
por: Ozgur, Tumay, et al.
Publicado: (2013)

Targeting iNOS to increase efficacy of immunotherapies
por: Ekmekcioglu, Suhendan, et al.
Publicado: (2017)

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)
por: Lalani, Salima, et al.
Publicado: (2020)

Protective effect of enterovirus-71 (EV71) virus-like particle vaccine against lethal EV71 infection in a neonatal mouse model
por: CAO, LEI, et al.
Publicado: (2015)

Upregulation of iNOS and phosphorylated eNOS in the implantation‐induced blastocysts of mice
por: Seki, Misato, et al.
Publicado: (2023)

EV71 vaccine, an invaluable gift for children
por: Liang, Zhenglun, et al.
Publicado: (2014)

iNOS polymorphism modulates iNOS/NO expression via impaired antioxidant and ROS content in P. vivax and P. falciparum infection
por: Kumar, Amod, et al.
Publicado: (2017)

Aging and Insulin Resistance: Just Say iNOS
por: Evans, Joseph L., et al.
Publicado: (2013)

Immune checkpoint inhibitor-induced neurotoxicity is not associated with seroprevalence of neurotropic infections
por: Schmitt, C., et al.
Publicado: (2023)

Phenotypic and Genotypic Characteristics of Novel Mouse Cell Line (NIH/3T3)-Adapted Human Enterovirus 71 Strains (EV71:TLLm and EV71:TLLmv)
por: Victorio, Carla Bianca Luena, et al.
Publicado: (2014)

Recipient iNOS but Not eNOS Deficiency Reduces Luminal Narrowing in Tracheal Allografts
por: Minamoto, Kanji, et al.
Publicado: (2002)

Sildenafil Ameliorates Gentamicin-Induced Nephrotoxicity in Rats: Role of iNOS and eNOS
por: Morsy, Mohamed A., et al.
Publicado: (2014)

Delivery of Human EV71 Receptors by Adeno-Associated Virus Increases EV71 Infection-Induced Local Inflammation in Adult Mice
por: Hsiao, Hung-Bo, et al.
Publicado: (2014)

The mature EV71 virion induced a broadly cross-neutralizing VP1 antibody against subtypes of the EV71 virus
por: Wu, Chia-Ying, et al.
Publicado: (2019)

The return of the Scarlet Pimpernel: cobalamin in inflammation II — cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS
por: Wheatley, Carmen
Publicado: (2007)

IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system
por: Franca, Rafael F. O., et al.
Publicado: (2016)

Supramolecular Bait to Trigger Non‐Equilibrium Co‐Assembly and Clearance of Aβ42
por: Wu, Te‐Haw, et al.
Publicado: (2020)

Correction: Phenotypic and Genotypic Characteristics of Novel Mouse Cell Line (NIH/3T3)-Adapted Human Enterovirus 71 Strains (EV71:TLLm and EV71:TLLmv)
Publicado: (2014)

Inhibition of EV71 by curcumin in intestinal epithelial cells
por: Huang, Hsing-I, et al.
Publicado: (2018)

Perthamide C Inhibits eNOS and iNOS Expression and Has Immunomodulating Activity In Vivo
por: Bucci, Mariarosaria, et al.
Publicado: (2013)

eNOS/iNOS and endoplasmic reticulum stress-induced apoptosis in the placentas of patients with preeclampsia
por: Du, L, et al.
Publicado: (2017)

The role of tumour-derived iNOS in tumour progression and angiogenesis
por: Kostourou, V, et al.
Publicado: (2011)

Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity
por: Torrisi, Jeremy S., et al.
Publicado: (2016)

Regulation of iNOS on Immune Cells and Its Role in Diseases
por: Xue, Qingjie, et al.
Publicado: (2018)

Hepatic Lysosomal iNOS Activity Impairs Autophagy in Obesity
por: Qian, Qingwen, et al.
Publicado: (2019)

The Potential Role of iNOS in Ovarian Cancer Progression and Chemoresistance
por: Kielbik, Michal, et al.
Publicado: (2019)

Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO
por: Kashfi, Khosrow, et al.
Publicado: (2021)

mRNA expression and localization of bNOS, eNOS and iNOS in human cervix at preterm and term labour
por: Törnblom, Susanne Abelin, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_v8a3nca1bq6edvf924dkfjjt5l