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Influential Factors on Survival in Gastric Cancer: A Single-center Study

BACKGROUND: Gastric cancer (GC) is one of the conspicuous causes of cancer-related death worldwide. Considering the mounting incidence of this cancer in developing countries such as Iran, determining the influential factors on the survival of involved patients is noteworthy. Hence, we aimed to ascer...

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Autores principales: Roshanaei, Ghodratollah, Kiumarsi, Azadeh, Kasaeian, Amir, Safari, Malihe, Abbasi, Mohammad, Rahimi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995304/
https://www.ncbi.nlm.nih.gov/pubmed/35419060
http://dx.doi.org/10.4103/jrms.JRMS_1286_20
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author Roshanaei, Ghodratollah
Kiumarsi, Azadeh
Kasaeian, Amir
Safari, Malihe
Abbasi, Mohammad
Rahimi, Ali
author_facet Roshanaei, Ghodratollah
Kiumarsi, Azadeh
Kasaeian, Amir
Safari, Malihe
Abbasi, Mohammad
Rahimi, Ali
author_sort Roshanaei, Ghodratollah
collection PubMed
description BACKGROUND: Gastric cancer (GC) is one of the conspicuous causes of cancer-related death worldwide. Considering the mounting incidence of this cancer in developing countries such as Iran, determining the influential factors on the survival of involved patients is noteworthy. Hence, we aimed to ascertain the survival rates and the prognostic factors in our GC patients. MATERIALS AND METHODS: In this retrospective cohort study, data of 314 patients with GC in a referral cancer center in Hamadan province of Iran were studied. The outcome of our study was survival time and the influential factors were gender, age at diagnosis, tumor history, tumor grade, surgery history, radiotherapy history, stage of disease, metastasis history, and lymph node involvement. Kaplan − Meier method and log-rank test were used for the calculation and comparing the survival curves and Cox-proportional hazard model was used for the multivariable analysis of prognostic factors. RESULTS: In a total of 314 GC patients, the median age at the diagnosis was 63 years (range: 21–92) with most patients (74.84%) being males. The median follow-up time was 2.42 years, and the median survival time was 2 years. The multivariable cox analysis of overall survival (OS) indicated that having distant metastasis increased the hazard of death by about 2.5 times (P < 0.0001, heart rates [HR]: 2.53, 95% confidence interval [CI]: [1.71, 3.75]), and receiving surgery as treatment, decreased the hazard of death up to 36% (P = 0.02, HR: 0.64, 95%CI: [0.46–0.89]). The other variables did not have any significant effects on the OS. CONCLUSION: The results of this study showed that lower survival (greater hazard of death) strongly and significantly associated with having distant metastasis in patients with GC and receiving surgery could significantly decrease the hazard of death in these patients instead.
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spelling pubmed-89953042022-04-12 Influential Factors on Survival in Gastric Cancer: A Single-center Study Roshanaei, Ghodratollah Kiumarsi, Azadeh Kasaeian, Amir Safari, Malihe Abbasi, Mohammad Rahimi, Ali J Res Med Sci Original Article BACKGROUND: Gastric cancer (GC) is one of the conspicuous causes of cancer-related death worldwide. Considering the mounting incidence of this cancer in developing countries such as Iran, determining the influential factors on the survival of involved patients is noteworthy. Hence, we aimed to ascertain the survival rates and the prognostic factors in our GC patients. MATERIALS AND METHODS: In this retrospective cohort study, data of 314 patients with GC in a referral cancer center in Hamadan province of Iran were studied. The outcome of our study was survival time and the influential factors were gender, age at diagnosis, tumor history, tumor grade, surgery history, radiotherapy history, stage of disease, metastasis history, and lymph node involvement. Kaplan − Meier method and log-rank test were used for the calculation and comparing the survival curves and Cox-proportional hazard model was used for the multivariable analysis of prognostic factors. RESULTS: In a total of 314 GC patients, the median age at the diagnosis was 63 years (range: 21–92) with most patients (74.84%) being males. The median follow-up time was 2.42 years, and the median survival time was 2 years. The multivariable cox analysis of overall survival (OS) indicated that having distant metastasis increased the hazard of death by about 2.5 times (P < 0.0001, heart rates [HR]: 2.53, 95% confidence interval [CI]: [1.71, 3.75]), and receiving surgery as treatment, decreased the hazard of death up to 36% (P = 0.02, HR: 0.64, 95%CI: [0.46–0.89]). The other variables did not have any significant effects on the OS. CONCLUSION: The results of this study showed that lower survival (greater hazard of death) strongly and significantly associated with having distant metastasis in patients with GC and receiving surgery could significantly decrease the hazard of death in these patients instead. Wolters Kluwer - Medknow 2022-03-17 /pmc/articles/PMC8995304/ /pubmed/35419060 http://dx.doi.org/10.4103/jrms.JRMS_1286_20 Text en Copyright: © 2022 Journal of Research in Medical Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Roshanaei, Ghodratollah
Kiumarsi, Azadeh
Kasaeian, Amir
Safari, Malihe
Abbasi, Mohammad
Rahimi, Ali
Influential Factors on Survival in Gastric Cancer: A Single-center Study
title Influential Factors on Survival in Gastric Cancer: A Single-center Study
title_full Influential Factors on Survival in Gastric Cancer: A Single-center Study
title_fullStr Influential Factors on Survival in Gastric Cancer: A Single-center Study
title_full_unstemmed Influential Factors on Survival in Gastric Cancer: A Single-center Study
title_short Influential Factors on Survival in Gastric Cancer: A Single-center Study
title_sort influential factors on survival in gastric cancer: a single-center study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995304/
https://www.ncbi.nlm.nih.gov/pubmed/35419060
http://dx.doi.org/10.4103/jrms.JRMS_1286_20
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