Cargando…

Long Non-Coding RNA Cancer Susceptibility Candidate 9 Regulates the Malignant Biological Behavior of Nasopharyngeal Carcinoma Cells by Targeting miR-497-5p/Wnt3a/β-catenin Signaling Pathway

Nasopharyngeal carcinoma (NPC) is a major kind of head and neck epithelial carcinoma. Increasing evidences reveal that long noncoding RNAs are considered as vital regulators in tumorigenesis and progression. Although previous studies have found that cancer susceptibility candidate 9 (CASC9) highly e...

Descripción completa

Detalles Bibliográficos
Autores principales: Lei, Yue, Luo, Wenlong, Gong, Qiuyue, Luo, Lan, Jing, Wuyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995468/
https://www.ncbi.nlm.nih.gov/pubmed/35419295
http://dx.doi.org/10.3389/fonc.2022.807052
_version_ 1784684304094199808
author Lei, Yue
Luo, Wenlong
Gong, Qiuyue
Luo, Lan
Jing, Wuyang
author_facet Lei, Yue
Luo, Wenlong
Gong, Qiuyue
Luo, Lan
Jing, Wuyang
author_sort Lei, Yue
collection PubMed
description Nasopharyngeal carcinoma (NPC) is a major kind of head and neck epithelial carcinoma. Increasing evidences reveal that long noncoding RNAs are considered as vital regulators in tumorigenesis and progression. Although previous studies have found that cancer susceptibility candidate 9 (CASC9) highly expresses in NPC, the underlying mechanisms need to be further studied. In this study, we found that CASC9 was overexpressed and associated with worse prognosis in NPC. CASC9 knockdown significantly inhibited the cell proliferation, migration and invasion in vitro and enhanced the sensitivity of tumor cells to cisplatin and paclitaxel. Mechanism research confirmed CASC9 regulated the malignant biological behavior of nasopharyngeal carcinoma cells by targeting miR-497-5p/Wnt3a/β-catenin signaling pathway. The present study might provide a novel mechanism for tumorigenesis and progression of NPC and contribute to the development of an effective molecular target therapy.
format Online
Article
Text
id pubmed-8995468
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89954682022-04-12 Long Non-Coding RNA Cancer Susceptibility Candidate 9 Regulates the Malignant Biological Behavior of Nasopharyngeal Carcinoma Cells by Targeting miR-497-5p/Wnt3a/β-catenin Signaling Pathway Lei, Yue Luo, Wenlong Gong, Qiuyue Luo, Lan Jing, Wuyang Front Oncol Oncology Nasopharyngeal carcinoma (NPC) is a major kind of head and neck epithelial carcinoma. Increasing evidences reveal that long noncoding RNAs are considered as vital regulators in tumorigenesis and progression. Although previous studies have found that cancer susceptibility candidate 9 (CASC9) highly expresses in NPC, the underlying mechanisms need to be further studied. In this study, we found that CASC9 was overexpressed and associated with worse prognosis in NPC. CASC9 knockdown significantly inhibited the cell proliferation, migration and invasion in vitro and enhanced the sensitivity of tumor cells to cisplatin and paclitaxel. Mechanism research confirmed CASC9 regulated the malignant biological behavior of nasopharyngeal carcinoma cells by targeting miR-497-5p/Wnt3a/β-catenin signaling pathway. The present study might provide a novel mechanism for tumorigenesis and progression of NPC and contribute to the development of an effective molecular target therapy. Frontiers Media S.A. 2022-03-28 /pmc/articles/PMC8995468/ /pubmed/35419295 http://dx.doi.org/10.3389/fonc.2022.807052 Text en Copyright © 2022 Lei, Luo, Gong, Luo and Jing https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Lei, Yue
Luo, Wenlong
Gong, Qiuyue
Luo, Lan
Jing, Wuyang
Long Non-Coding RNA Cancer Susceptibility Candidate 9 Regulates the Malignant Biological Behavior of Nasopharyngeal Carcinoma Cells by Targeting miR-497-5p/Wnt3a/β-catenin Signaling Pathway
title Long Non-Coding RNA Cancer Susceptibility Candidate 9 Regulates the Malignant Biological Behavior of Nasopharyngeal Carcinoma Cells by Targeting miR-497-5p/Wnt3a/β-catenin Signaling Pathway
title_full Long Non-Coding RNA Cancer Susceptibility Candidate 9 Regulates the Malignant Biological Behavior of Nasopharyngeal Carcinoma Cells by Targeting miR-497-5p/Wnt3a/β-catenin Signaling Pathway
title_fullStr Long Non-Coding RNA Cancer Susceptibility Candidate 9 Regulates the Malignant Biological Behavior of Nasopharyngeal Carcinoma Cells by Targeting miR-497-5p/Wnt3a/β-catenin Signaling Pathway
title_full_unstemmed Long Non-Coding RNA Cancer Susceptibility Candidate 9 Regulates the Malignant Biological Behavior of Nasopharyngeal Carcinoma Cells by Targeting miR-497-5p/Wnt3a/β-catenin Signaling Pathway
title_short Long Non-Coding RNA Cancer Susceptibility Candidate 9 Regulates the Malignant Biological Behavior of Nasopharyngeal Carcinoma Cells by Targeting miR-497-5p/Wnt3a/β-catenin Signaling Pathway
title_sort long non-coding rna cancer susceptibility candidate 9 regulates the malignant biological behavior of nasopharyngeal carcinoma cells by targeting mir-497-5p/wnt3a/β-catenin signaling pathway
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995468/
https://www.ncbi.nlm.nih.gov/pubmed/35419295
http://dx.doi.org/10.3389/fonc.2022.807052
work_keys_str_mv AT leiyue longnoncodingrnacancersusceptibilitycandidate9regulatesthemalignantbiologicalbehaviorofnasopharyngealcarcinomacellsbytargetingmir4975pwnt3abcateninsignalingpathway
AT luowenlong longnoncodingrnacancersusceptibilitycandidate9regulatesthemalignantbiologicalbehaviorofnasopharyngealcarcinomacellsbytargetingmir4975pwnt3abcateninsignalingpathway
AT gongqiuyue longnoncodingrnacancersusceptibilitycandidate9regulatesthemalignantbiologicalbehaviorofnasopharyngealcarcinomacellsbytargetingmir4975pwnt3abcateninsignalingpathway
AT luolan longnoncodingrnacancersusceptibilitycandidate9regulatesthemalignantbiologicalbehaviorofnasopharyngealcarcinomacellsbytargetingmir4975pwnt3abcateninsignalingpathway
AT jingwuyang longnoncodingrnacancersusceptibilitycandidate9regulatesthemalignantbiologicalbehaviorofnasopharyngealcarcinomacellsbytargetingmir4975pwnt3abcateninsignalingpathway