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Altered Cingulum Functioning in Major Depressive Disorder Patient With Suicide Attempts: A Resting-State Functional Magnetic Resonance Imaging Study

BACKGROUND: Major depressive disorder (MDD) with suicide attempts (SA) poses a significant public health issue. This study aims to identify neurobiological markers for MDD with SA on resting-state brain functional magnetic resonance imaging (rs-fMRI). METHODS: Fifty-one unmedicated adult MDD partici...

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Autores principales: Yang, Chunxia, Duan, Yajuan, Lei, Lei, Liu, Penghong, Zhang, Aixia, Li, Gaizhi, Sun, Ning, Wang, Yikun, Liu, Zhifen, Zhang, Kerang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995705/
https://www.ncbi.nlm.nih.gov/pubmed/35418833
http://dx.doi.org/10.3389/fnins.2022.849158
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author Yang, Chunxia
Duan, Yajuan
Lei, Lei
Liu, Penghong
Zhang, Aixia
Li, Gaizhi
Sun, Ning
Wang, Yikun
Liu, Zhifen
Zhang, Kerang
author_facet Yang, Chunxia
Duan, Yajuan
Lei, Lei
Liu, Penghong
Zhang, Aixia
Li, Gaizhi
Sun, Ning
Wang, Yikun
Liu, Zhifen
Zhang, Kerang
author_sort Yang, Chunxia
collection PubMed
description BACKGROUND: Major depressive disorder (MDD) with suicide attempts (SA) poses a significant public health issue. This study aims to identify neurobiological markers for MDD with SA on resting-state brain functional magnetic resonance imaging (rs-fMRI). METHODS: Fifty-one unmedicated adult MDD participants, 27 with SA on the Beck Scale for Suicidal Ideation and 24 without SA, underwent rs-fMRI scanning. A group of 30 healthy controls (HC) matched for age, gender, and education-level with MDD were chosen. A whole brain analysis of regional homogeneity (ReHo) was performed on subjects to identify regions where brain activity was associated with SA. Multiple comparison analysis was performed for ReHo. Pearson’s correlation analysis was performed between HAMD-SA scores and ReHo. The statistical significance level was set at p < 0.05. RESULTS: We examined whether there were significant differences among the three groups in whole brain ReHo during resting state. Subjects with SA showed significant increase of ReHo in the right Cingulum Post in comparison with those without SA. Subjects with SA showed significant decrease of ReHo in the right Cingulate Gyrus/Precuneus in comparison with HC. The mean ReHo from the significant brain region was associated with HAMD-SA (item 3 of the HAMD) scores (r = 0.349, P = 0.012) but was not associated with HAMD-24 scores. CONCLUSION: These results indicate that SA is associated with altered resting-state brain activity. The pattern of elevated activity in the cingulum functioning may be related to SA. Identifying cingulum activity associated with SA may help to elucidate its pathogenesis and etiology.
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spelling pubmed-89957052022-04-12 Altered Cingulum Functioning in Major Depressive Disorder Patient With Suicide Attempts: A Resting-State Functional Magnetic Resonance Imaging Study Yang, Chunxia Duan, Yajuan Lei, Lei Liu, Penghong Zhang, Aixia Li, Gaizhi Sun, Ning Wang, Yikun Liu, Zhifen Zhang, Kerang Front Neurosci Neuroscience BACKGROUND: Major depressive disorder (MDD) with suicide attempts (SA) poses a significant public health issue. This study aims to identify neurobiological markers for MDD with SA on resting-state brain functional magnetic resonance imaging (rs-fMRI). METHODS: Fifty-one unmedicated adult MDD participants, 27 with SA on the Beck Scale for Suicidal Ideation and 24 without SA, underwent rs-fMRI scanning. A group of 30 healthy controls (HC) matched for age, gender, and education-level with MDD were chosen. A whole brain analysis of regional homogeneity (ReHo) was performed on subjects to identify regions where brain activity was associated with SA. Multiple comparison analysis was performed for ReHo. Pearson’s correlation analysis was performed between HAMD-SA scores and ReHo. The statistical significance level was set at p < 0.05. RESULTS: We examined whether there were significant differences among the three groups in whole brain ReHo during resting state. Subjects with SA showed significant increase of ReHo in the right Cingulum Post in comparison with those without SA. Subjects with SA showed significant decrease of ReHo in the right Cingulate Gyrus/Precuneus in comparison with HC. The mean ReHo from the significant brain region was associated with HAMD-SA (item 3 of the HAMD) scores (r = 0.349, P = 0.012) but was not associated with HAMD-24 scores. CONCLUSION: These results indicate that SA is associated with altered resting-state brain activity. The pattern of elevated activity in the cingulum functioning may be related to SA. Identifying cingulum activity associated with SA may help to elucidate its pathogenesis and etiology. Frontiers Media S.A. 2022-03-28 /pmc/articles/PMC8995705/ /pubmed/35418833 http://dx.doi.org/10.3389/fnins.2022.849158 Text en Copyright © 2022 Yang, Duan, Lei, Liu, Zhang, Li, Sun, Wang, Liu and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Yang, Chunxia
Duan, Yajuan
Lei, Lei
Liu, Penghong
Zhang, Aixia
Li, Gaizhi
Sun, Ning
Wang, Yikun
Liu, Zhifen
Zhang, Kerang
Altered Cingulum Functioning in Major Depressive Disorder Patient With Suicide Attempts: A Resting-State Functional Magnetic Resonance Imaging Study
title Altered Cingulum Functioning in Major Depressive Disorder Patient With Suicide Attempts: A Resting-State Functional Magnetic Resonance Imaging Study
title_full Altered Cingulum Functioning in Major Depressive Disorder Patient With Suicide Attempts: A Resting-State Functional Magnetic Resonance Imaging Study
title_fullStr Altered Cingulum Functioning in Major Depressive Disorder Patient With Suicide Attempts: A Resting-State Functional Magnetic Resonance Imaging Study
title_full_unstemmed Altered Cingulum Functioning in Major Depressive Disorder Patient With Suicide Attempts: A Resting-State Functional Magnetic Resonance Imaging Study
title_short Altered Cingulum Functioning in Major Depressive Disorder Patient With Suicide Attempts: A Resting-State Functional Magnetic Resonance Imaging Study
title_sort altered cingulum functioning in major depressive disorder patient with suicide attempts: a resting-state functional magnetic resonance imaging study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995705/
https://www.ncbi.nlm.nih.gov/pubmed/35418833
http://dx.doi.org/10.3389/fnins.2022.849158
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