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SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience

BACKGROUND: The COVID-19 pandemic has significantly impacted the management of solid organ transplant recipients and on clinical evolution in post-transplantation. Little is known on the impact of SARS-CoV-2 infection in these patients. The severity and lethality of this disease in solid organ trans...

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Autores principales: Pinchera, Biagio, Spirito, Lorenzo, Ferreri, Lucia, Rocca, Roberto La, Celentano, Giuseppe, Buonomo, Antonio Riccardo, Foggia, Maria, Scotto, Riccardo, Federico, Stefano, Gentile, Ivan, Carrano, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995796/
https://www.ncbi.nlm.nih.gov/pubmed/35419375
http://dx.doi.org/10.3389/fmed.2022.864865
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author Pinchera, Biagio
Spirito, Lorenzo
Ferreri, Lucia
Rocca, Roberto La
Celentano, Giuseppe
Buonomo, Antonio Riccardo
Foggia, Maria
Scotto, Riccardo
Federico, Stefano
Gentile, Ivan
Carrano, Rosa
author_facet Pinchera, Biagio
Spirito, Lorenzo
Ferreri, Lucia
Rocca, Roberto La
Celentano, Giuseppe
Buonomo, Antonio Riccardo
Foggia, Maria
Scotto, Riccardo
Federico, Stefano
Gentile, Ivan
Carrano, Rosa
author_sort Pinchera, Biagio
collection PubMed
description BACKGROUND: The COVID-19 pandemic has significantly impacted the management of solid organ transplant recipients and on clinical evolution in post-transplantation. Little is known on the impact of SARS-CoV-2 infection in these patients. The severity and lethality of this disease in solid organ transplant patients are higher thanin the general population. This study aims to describe clinical characteristics of SARS-CoV-2 infection in solid organ transplant recipients followed in our center. METHODS: In this observational study, we enrolled all kidney transplant recipientsattending the A.O.U. Federico II of Naples from March 2020 to January 2021. For each patient we evaluated the epidemiological and clinical characteristics as well as outcome. RESULTS: We enrolled 369 kidney transplant patients (229, male, 62%). Of these, 51 (13.8%) acquired SARS-CoV-2 infection and 29 showed symptomatic disease. Of the 51 patients with the infection, 48 (94.11%) had at least one comorbidity and such comorbidities did not constitute a risk factor for a more severe disease. Hospitalization was necessary for 7 (13.7%) patients. Of these, 2 required low-flow oxygen supplementation, 3 non-invasive/high flow ventilation and 2 invasive ventilation. Finally, 2 patients died. CONCLUSIONS: Our study shows a lower mortality and hospitalization rate compared to figures available in the literature (4% vs. 13–30% and 14% vs. 32–100%, respectively). Furthermore, the comorbidities examined (hypertension, dyslipidemia, and diabetes) did not constitute a risk factor for a more severe disease condition in this patient category. Further studies with larger sample size are necessary to confirm these data.
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spelling pubmed-89957962022-04-12 SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience Pinchera, Biagio Spirito, Lorenzo Ferreri, Lucia Rocca, Roberto La Celentano, Giuseppe Buonomo, Antonio Riccardo Foggia, Maria Scotto, Riccardo Federico, Stefano Gentile, Ivan Carrano, Rosa Front Med (Lausanne) Medicine BACKGROUND: The COVID-19 pandemic has significantly impacted the management of solid organ transplant recipients and on clinical evolution in post-transplantation. Little is known on the impact of SARS-CoV-2 infection in these patients. The severity and lethality of this disease in solid organ transplant patients are higher thanin the general population. This study aims to describe clinical characteristics of SARS-CoV-2 infection in solid organ transplant recipients followed in our center. METHODS: In this observational study, we enrolled all kidney transplant recipientsattending the A.O.U. Federico II of Naples from March 2020 to January 2021. For each patient we evaluated the epidemiological and clinical characteristics as well as outcome. RESULTS: We enrolled 369 kidney transplant patients (229, male, 62%). Of these, 51 (13.8%) acquired SARS-CoV-2 infection and 29 showed symptomatic disease. Of the 51 patients with the infection, 48 (94.11%) had at least one comorbidity and such comorbidities did not constitute a risk factor for a more severe disease. Hospitalization was necessary for 7 (13.7%) patients. Of these, 2 required low-flow oxygen supplementation, 3 non-invasive/high flow ventilation and 2 invasive ventilation. Finally, 2 patients died. CONCLUSIONS: Our study shows a lower mortality and hospitalization rate compared to figures available in the literature (4% vs. 13–30% and 14% vs. 32–100%, respectively). Furthermore, the comorbidities examined (hypertension, dyslipidemia, and diabetes) did not constitute a risk factor for a more severe disease condition in this patient category. Further studies with larger sample size are necessary to confirm these data. Frontiers Media S.A. 2022-03-28 /pmc/articles/PMC8995796/ /pubmed/35419375 http://dx.doi.org/10.3389/fmed.2022.864865 Text en Copyright © 2022 Pinchera, Spirito, Ferreri, Rocca, Celentano, Buonomo, Foggia, Scotto, Federico, Gentile, Carrano and “Federico II” COVID-19 Team. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Pinchera, Biagio
Spirito, Lorenzo
Ferreri, Lucia
Rocca, Roberto La
Celentano, Giuseppe
Buonomo, Antonio Riccardo
Foggia, Maria
Scotto, Riccardo
Federico, Stefano
Gentile, Ivan
Carrano, Rosa
SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience
title SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience
title_full SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience
title_fullStr SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience
title_full_unstemmed SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience
title_short SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience
title_sort sars-cov-2 in kidney transplant patients: a real-life experience
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995796/
https://www.ncbi.nlm.nih.gov/pubmed/35419375
http://dx.doi.org/10.3389/fmed.2022.864865
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