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SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience
BACKGROUND: The COVID-19 pandemic has significantly impacted the management of solid organ transplant recipients and on clinical evolution in post-transplantation. Little is known on the impact of SARS-CoV-2 infection in these patients. The severity and lethality of this disease in solid organ trans...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995796/ https://www.ncbi.nlm.nih.gov/pubmed/35419375 http://dx.doi.org/10.3389/fmed.2022.864865 |
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author | Pinchera, Biagio Spirito, Lorenzo Ferreri, Lucia Rocca, Roberto La Celentano, Giuseppe Buonomo, Antonio Riccardo Foggia, Maria Scotto, Riccardo Federico, Stefano Gentile, Ivan Carrano, Rosa |
author_facet | Pinchera, Biagio Spirito, Lorenzo Ferreri, Lucia Rocca, Roberto La Celentano, Giuseppe Buonomo, Antonio Riccardo Foggia, Maria Scotto, Riccardo Federico, Stefano Gentile, Ivan Carrano, Rosa |
author_sort | Pinchera, Biagio |
collection | PubMed |
description | BACKGROUND: The COVID-19 pandemic has significantly impacted the management of solid organ transplant recipients and on clinical evolution in post-transplantation. Little is known on the impact of SARS-CoV-2 infection in these patients. The severity and lethality of this disease in solid organ transplant patients are higher thanin the general population. This study aims to describe clinical characteristics of SARS-CoV-2 infection in solid organ transplant recipients followed in our center. METHODS: In this observational study, we enrolled all kidney transplant recipientsattending the A.O.U. Federico II of Naples from March 2020 to January 2021. For each patient we evaluated the epidemiological and clinical characteristics as well as outcome. RESULTS: We enrolled 369 kidney transplant patients (229, male, 62%). Of these, 51 (13.8%) acquired SARS-CoV-2 infection and 29 showed symptomatic disease. Of the 51 patients with the infection, 48 (94.11%) had at least one comorbidity and such comorbidities did not constitute a risk factor for a more severe disease. Hospitalization was necessary for 7 (13.7%) patients. Of these, 2 required low-flow oxygen supplementation, 3 non-invasive/high flow ventilation and 2 invasive ventilation. Finally, 2 patients died. CONCLUSIONS: Our study shows a lower mortality and hospitalization rate compared to figures available in the literature (4% vs. 13–30% and 14% vs. 32–100%, respectively). Furthermore, the comorbidities examined (hypertension, dyslipidemia, and diabetes) did not constitute a risk factor for a more severe disease condition in this patient category. Further studies with larger sample size are necessary to confirm these data. |
format | Online Article Text |
id | pubmed-8995796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89957962022-04-12 SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience Pinchera, Biagio Spirito, Lorenzo Ferreri, Lucia Rocca, Roberto La Celentano, Giuseppe Buonomo, Antonio Riccardo Foggia, Maria Scotto, Riccardo Federico, Stefano Gentile, Ivan Carrano, Rosa Front Med (Lausanne) Medicine BACKGROUND: The COVID-19 pandemic has significantly impacted the management of solid organ transplant recipients and on clinical evolution in post-transplantation. Little is known on the impact of SARS-CoV-2 infection in these patients. The severity and lethality of this disease in solid organ transplant patients are higher thanin the general population. This study aims to describe clinical characteristics of SARS-CoV-2 infection in solid organ transplant recipients followed in our center. METHODS: In this observational study, we enrolled all kidney transplant recipientsattending the A.O.U. Federico II of Naples from March 2020 to January 2021. For each patient we evaluated the epidemiological and clinical characteristics as well as outcome. RESULTS: We enrolled 369 kidney transplant patients (229, male, 62%). Of these, 51 (13.8%) acquired SARS-CoV-2 infection and 29 showed symptomatic disease. Of the 51 patients with the infection, 48 (94.11%) had at least one comorbidity and such comorbidities did not constitute a risk factor for a more severe disease. Hospitalization was necessary for 7 (13.7%) patients. Of these, 2 required low-flow oxygen supplementation, 3 non-invasive/high flow ventilation and 2 invasive ventilation. Finally, 2 patients died. CONCLUSIONS: Our study shows a lower mortality and hospitalization rate compared to figures available in the literature (4% vs. 13–30% and 14% vs. 32–100%, respectively). Furthermore, the comorbidities examined (hypertension, dyslipidemia, and diabetes) did not constitute a risk factor for a more severe disease condition in this patient category. Further studies with larger sample size are necessary to confirm these data. Frontiers Media S.A. 2022-03-28 /pmc/articles/PMC8995796/ /pubmed/35419375 http://dx.doi.org/10.3389/fmed.2022.864865 Text en Copyright © 2022 Pinchera, Spirito, Ferreri, Rocca, Celentano, Buonomo, Foggia, Scotto, Federico, Gentile, Carrano and “Federico II” COVID-19 Team. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Pinchera, Biagio Spirito, Lorenzo Ferreri, Lucia Rocca, Roberto La Celentano, Giuseppe Buonomo, Antonio Riccardo Foggia, Maria Scotto, Riccardo Federico, Stefano Gentile, Ivan Carrano, Rosa SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience |
title | SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience |
title_full | SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience |
title_fullStr | SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience |
title_full_unstemmed | SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience |
title_short | SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience |
title_sort | sars-cov-2 in kidney transplant patients: a real-life experience |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995796/ https://www.ncbi.nlm.nih.gov/pubmed/35419375 http://dx.doi.org/10.3389/fmed.2022.864865 |
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