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Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China
Chicken infectious anemia (CIA) is an immunosuppressive disease caused by the chicken infectious anemia virus (CIAV) resulting in heavy economic losses once an outbreak is established. This study conducted a systematic analysis of the epidemiology and pathology of CIA in Henan province, China. A tot...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995968/ https://www.ncbi.nlm.nih.gov/pubmed/35419450 http://dx.doi.org/10.3389/fvets.2022.871826 |
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author | Wang, Xin-Wei Feng, Jie Jin, Jia-Xin Zhu, Xiao-Jing Sun, Ai-Jun Liu, Hua-Yuan Wang, Jing-Jing Wang, Rui Yang, Xia Chen, Lu Liao, Yi-Fei Zhuang, Guo-Qing |
author_facet | Wang, Xin-Wei Feng, Jie Jin, Jia-Xin Zhu, Xiao-Jing Sun, Ai-Jun Liu, Hua-Yuan Wang, Jing-Jing Wang, Rui Yang, Xia Chen, Lu Liao, Yi-Fei Zhuang, Guo-Qing |
author_sort | Wang, Xin-Wei |
collection | PubMed |
description | Chicken infectious anemia (CIA) is an immunosuppressive disease caused by the chicken infectious anemia virus (CIAV) resulting in heavy economic losses once an outbreak is established. This study conducted a systematic analysis of the epidemiology and pathology of CIA in Henan province, China. A total of 437 clinical tissue samples and 120 poultry disease-related live attenuated vaccines were collected during 2017–2020; of which 45 were positive for CIAV nucleic acid, with a positive rate of 8.08%. Our results showed that genome sequence similarity among a total of 12 CIAV isolates was high, and ranged from 97.1 to 99.3%, and their similarity to the vaccine strains Cux-1 and Del-Ros ranged from 97.8 to 98.6%. However, There were mutations in the locus of the major capsid proteins VP1, VP2, and VP3 among all isolates. The subsequent sequence analysis indicated that the isolates of HN-4 and HN-8 showed genetic recombination and follow up animal experiments revealed that HN-4 might be a pathogenic strain. Our results reveal that both field infection and non-CIAV vaccines contamination promote the epidemiology of CIAV in China and some dominant epidemic viruses have undergone recombination and evolution. This study provides important information to help with the prevention and control of CIAV in the poultry industry. |
format | Online Article Text |
id | pubmed-8995968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89959682022-04-12 Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China Wang, Xin-Wei Feng, Jie Jin, Jia-Xin Zhu, Xiao-Jing Sun, Ai-Jun Liu, Hua-Yuan Wang, Jing-Jing Wang, Rui Yang, Xia Chen, Lu Liao, Yi-Fei Zhuang, Guo-Qing Front Vet Sci Veterinary Science Chicken infectious anemia (CIA) is an immunosuppressive disease caused by the chicken infectious anemia virus (CIAV) resulting in heavy economic losses once an outbreak is established. This study conducted a systematic analysis of the epidemiology and pathology of CIA in Henan province, China. A total of 437 clinical tissue samples and 120 poultry disease-related live attenuated vaccines were collected during 2017–2020; of which 45 were positive for CIAV nucleic acid, with a positive rate of 8.08%. Our results showed that genome sequence similarity among a total of 12 CIAV isolates was high, and ranged from 97.1 to 99.3%, and their similarity to the vaccine strains Cux-1 and Del-Ros ranged from 97.8 to 98.6%. However, There were mutations in the locus of the major capsid proteins VP1, VP2, and VP3 among all isolates. The subsequent sequence analysis indicated that the isolates of HN-4 and HN-8 showed genetic recombination and follow up animal experiments revealed that HN-4 might be a pathogenic strain. Our results reveal that both field infection and non-CIAV vaccines contamination promote the epidemiology of CIAV in China and some dominant epidemic viruses have undergone recombination and evolution. This study provides important information to help with the prevention and control of CIAV in the poultry industry. Frontiers Media S.A. 2022-03-28 /pmc/articles/PMC8995968/ /pubmed/35419450 http://dx.doi.org/10.3389/fvets.2022.871826 Text en Copyright © 2022 Wang, Feng, Jin, Zhu, Sun, Liu, Wang, Wang, Yang, Chen, Liao and Zhuang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Wang, Xin-Wei Feng, Jie Jin, Jia-Xin Zhu, Xiao-Jing Sun, Ai-Jun Liu, Hua-Yuan Wang, Jing-Jing Wang, Rui Yang, Xia Chen, Lu Liao, Yi-Fei Zhuang, Guo-Qing Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China |
title | Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China |
title_full | Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China |
title_fullStr | Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China |
title_full_unstemmed | Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China |
title_short | Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China |
title_sort | molecular epidemiology and pathogenic characterization of novel chicken infectious anemia viruses in henan province of china |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995968/ https://www.ncbi.nlm.nih.gov/pubmed/35419450 http://dx.doi.org/10.3389/fvets.2022.871826 |
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