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Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China

Chicken infectious anemia (CIA) is an immunosuppressive disease caused by the chicken infectious anemia virus (CIAV) resulting in heavy economic losses once an outbreak is established. This study conducted a systematic analysis of the epidemiology and pathology of CIA in Henan province, China. A tot...

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Autores principales: Wang, Xin-Wei, Feng, Jie, Jin, Jia-Xin, Zhu, Xiao-Jing, Sun, Ai-Jun, Liu, Hua-Yuan, Wang, Jing-Jing, Wang, Rui, Yang, Xia, Chen, Lu, Liao, Yi-Fei, Zhuang, Guo-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995968/
https://www.ncbi.nlm.nih.gov/pubmed/35419450
http://dx.doi.org/10.3389/fvets.2022.871826
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author Wang, Xin-Wei
Feng, Jie
Jin, Jia-Xin
Zhu, Xiao-Jing
Sun, Ai-Jun
Liu, Hua-Yuan
Wang, Jing-Jing
Wang, Rui
Yang, Xia
Chen, Lu
Liao, Yi-Fei
Zhuang, Guo-Qing
author_facet Wang, Xin-Wei
Feng, Jie
Jin, Jia-Xin
Zhu, Xiao-Jing
Sun, Ai-Jun
Liu, Hua-Yuan
Wang, Jing-Jing
Wang, Rui
Yang, Xia
Chen, Lu
Liao, Yi-Fei
Zhuang, Guo-Qing
author_sort Wang, Xin-Wei
collection PubMed
description Chicken infectious anemia (CIA) is an immunosuppressive disease caused by the chicken infectious anemia virus (CIAV) resulting in heavy economic losses once an outbreak is established. This study conducted a systematic analysis of the epidemiology and pathology of CIA in Henan province, China. A total of 437 clinical tissue samples and 120 poultry disease-related live attenuated vaccines were collected during 2017–2020; of which 45 were positive for CIAV nucleic acid, with a positive rate of 8.08%. Our results showed that genome sequence similarity among a total of 12 CIAV isolates was high, and ranged from 97.1 to 99.3%, and their similarity to the vaccine strains Cux-1 and Del-Ros ranged from 97.8 to 98.6%. However, There were mutations in the locus of the major capsid proteins VP1, VP2, and VP3 among all isolates. The subsequent sequence analysis indicated that the isolates of HN-4 and HN-8 showed genetic recombination and follow up animal experiments revealed that HN-4 might be a pathogenic strain. Our results reveal that both field infection and non-CIAV vaccines contamination promote the epidemiology of CIAV in China and some dominant epidemic viruses have undergone recombination and evolution. This study provides important information to help with the prevention and control of CIAV in the poultry industry.
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spelling pubmed-89959682022-04-12 Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China Wang, Xin-Wei Feng, Jie Jin, Jia-Xin Zhu, Xiao-Jing Sun, Ai-Jun Liu, Hua-Yuan Wang, Jing-Jing Wang, Rui Yang, Xia Chen, Lu Liao, Yi-Fei Zhuang, Guo-Qing Front Vet Sci Veterinary Science Chicken infectious anemia (CIA) is an immunosuppressive disease caused by the chicken infectious anemia virus (CIAV) resulting in heavy economic losses once an outbreak is established. This study conducted a systematic analysis of the epidemiology and pathology of CIA in Henan province, China. A total of 437 clinical tissue samples and 120 poultry disease-related live attenuated vaccines were collected during 2017–2020; of which 45 were positive for CIAV nucleic acid, with a positive rate of 8.08%. Our results showed that genome sequence similarity among a total of 12 CIAV isolates was high, and ranged from 97.1 to 99.3%, and their similarity to the vaccine strains Cux-1 and Del-Ros ranged from 97.8 to 98.6%. However, There were mutations in the locus of the major capsid proteins VP1, VP2, and VP3 among all isolates. The subsequent sequence analysis indicated that the isolates of HN-4 and HN-8 showed genetic recombination and follow up animal experiments revealed that HN-4 might be a pathogenic strain. Our results reveal that both field infection and non-CIAV vaccines contamination promote the epidemiology of CIAV in China and some dominant epidemic viruses have undergone recombination and evolution. This study provides important information to help with the prevention and control of CIAV in the poultry industry. Frontiers Media S.A. 2022-03-28 /pmc/articles/PMC8995968/ /pubmed/35419450 http://dx.doi.org/10.3389/fvets.2022.871826 Text en Copyright © 2022 Wang, Feng, Jin, Zhu, Sun, Liu, Wang, Wang, Yang, Chen, Liao and Zhuang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Wang, Xin-Wei
Feng, Jie
Jin, Jia-Xin
Zhu, Xiao-Jing
Sun, Ai-Jun
Liu, Hua-Yuan
Wang, Jing-Jing
Wang, Rui
Yang, Xia
Chen, Lu
Liao, Yi-Fei
Zhuang, Guo-Qing
Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China
title Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China
title_full Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China
title_fullStr Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China
title_full_unstemmed Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China
title_short Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China
title_sort molecular epidemiology and pathogenic characterization of novel chicken infectious anemia viruses in henan province of china
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995968/
https://www.ncbi.nlm.nih.gov/pubmed/35419450
http://dx.doi.org/10.3389/fvets.2022.871826
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