Enhanced RAGE Expression and Excess Reactive-Oxygen Species Production Mediates Rho Kinase-Dependent Detrusor Overactivity After Methylglyoxal Exposure

Methylglyoxal (MGO) is a highly reactive dicarbonyl compound implicated in diabetes-associated diseases. In vascular tissues, MGO induces the formation of advanced glycation end products (AGEs) that bounds its receptor RAGE, initiating the downstream tissue injury. Outside the cardiovascular system,...

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Detalles Bibliográficos
Autores principales: Oliveira, Akila L., Medeiros, Matheus L., de Oliveira, Mariana G., Teixeira, Caio Jordão, Mónica, Fabíola Z., Antunes, Edson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996136/
https://www.ncbi.nlm.nih.gov/pubmed/35418871
http://dx.doi.org/10.3389/fphys.2022.860342

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