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Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP(+)/NADPH and the substrate folic acid

Pteridine reductase 1 (PTR1) is a key enzyme of the folate pathway in protozoan parasites of the genera Leishmania and Trypanosoma and is a valuable drug target for tropical diseases. This enzyme is able to catalyze the NADPH-dependent reduction of both conjugated (folate) and unconjugated (biopteri...

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Detalles Bibliográficos
Autores principales:	Dello Iacono, Lucia, Di Pisa, Flavio, Mangani, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2022
Materias:	Research Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996148/ https://www.ncbi.nlm.nih.gov/pubmed/35400669 http://dx.doi.org/10.1107/S2053230X22002795

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