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Vascular Inflammation in Mouse Models of Systemic Lupus Erythematosus
Vascular inflammation mediated by overly activated immune cells is a significant cause of morbidity and mortality in systemic lupus erythematosus (SLE). Several mouse models to study the pathogenesis of SLE are currently in use, many of which have different mechanisms of pathogenesis. The diversity...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996195/ https://www.ncbi.nlm.nih.gov/pubmed/35419427 http://dx.doi.org/10.3389/fcvm.2022.767450 |
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author | Ryan, Holly Morel, Laurence Moore, Erika |
author_facet | Ryan, Holly Morel, Laurence Moore, Erika |
author_sort | Ryan, Holly |
collection | PubMed |
description | Vascular inflammation mediated by overly activated immune cells is a significant cause of morbidity and mortality in systemic lupus erythematosus (SLE). Several mouse models to study the pathogenesis of SLE are currently in use, many of which have different mechanisms of pathogenesis. The diversity of these models allows interrogation of different aspects of the disease pathogenesis. To better determine the mechanisms by which vascular inflammation occurs in SLE, and to assist future researchers in choosing the most appropriate mouse models to study cardiovascular complications in SLE, we suggest that direct comparisons of vascular inflammation should be conducted among different murine SLE models. We also propose the use of in vitro vascular assays to further investigate vascular inflammation processes prevalent among different murine SLE models. |
format | Online Article Text |
id | pubmed-8996195 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89961952022-04-12 Vascular Inflammation in Mouse Models of Systemic Lupus Erythematosus Ryan, Holly Morel, Laurence Moore, Erika Front Cardiovasc Med Cardiovascular Medicine Vascular inflammation mediated by overly activated immune cells is a significant cause of morbidity and mortality in systemic lupus erythematosus (SLE). Several mouse models to study the pathogenesis of SLE are currently in use, many of which have different mechanisms of pathogenesis. The diversity of these models allows interrogation of different aspects of the disease pathogenesis. To better determine the mechanisms by which vascular inflammation occurs in SLE, and to assist future researchers in choosing the most appropriate mouse models to study cardiovascular complications in SLE, we suggest that direct comparisons of vascular inflammation should be conducted among different murine SLE models. We also propose the use of in vitro vascular assays to further investigate vascular inflammation processes prevalent among different murine SLE models. Frontiers Media S.A. 2022-03-28 /pmc/articles/PMC8996195/ /pubmed/35419427 http://dx.doi.org/10.3389/fcvm.2022.767450 Text en Copyright © 2022 Ryan, Morel and Moore. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Ryan, Holly Morel, Laurence Moore, Erika Vascular Inflammation in Mouse Models of Systemic Lupus Erythematosus |
title | Vascular Inflammation in Mouse Models of Systemic Lupus Erythematosus |
title_full | Vascular Inflammation in Mouse Models of Systemic Lupus Erythematosus |
title_fullStr | Vascular Inflammation in Mouse Models of Systemic Lupus Erythematosus |
title_full_unstemmed | Vascular Inflammation in Mouse Models of Systemic Lupus Erythematosus |
title_short | Vascular Inflammation in Mouse Models of Systemic Lupus Erythematosus |
title_sort | vascular inflammation in mouse models of systemic lupus erythematosus |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996195/ https://www.ncbi.nlm.nih.gov/pubmed/35419427 http://dx.doi.org/10.3389/fcvm.2022.767450 |
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