Immunogenicity and Protective Efficacy of a Highly Thermotolerant, Trimeric SARS-CoV-2 Receptor Binding Domain Derivative

[Image: see text] The receptor binding domain (RBD) of SARS-CoV-2 is the primary target of neutralizing antibodies. We designed a trimeric, highly thermotolerant glycan engineered RBD by fusion to a heterologous, poorly immunogenic disulfide linked trimerization domain derived from cartilage matrix...

Descripción completa

Detalles Bibliográficos
Autores principales: Malladi, Sameer Kumar, Patel, Unnatiben Rajeshbhai, Rajmani, Raju S., Singh, Randhir, Pandey, Suman, Kumar, Sahil, Khaleeq, Sara, van Vuren, Petrus Jansen, Riddell, Shane, Goldie, Sarah, Gayathri, Savitha, Chakraborty, Debajyoti, Kalita, Parismita, Pramanick, Ishika, Agarwal, Nupur, Reddy, Poorvi, Girish, Nidhi, Upadhyaya, Aditya, Khan, Mohammad Suhail, Kanjo, Kawkab, Bhat, Madhuraj, Mani, Shailendra, Bhattacharyya, Sankar, Siddiqui, Samreen, Tyagi, Akansha, Jha, Sujeet, Pandey, Rajesh, Tripathi, Shashank, Dutta, Somnath, McAuley, Alexander J., Singanallur, Nagendrakumar Balasubramanian, Vasan, Seshadri S., Ringe, Rajesh P., Varadarajan, Raghavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996237/
https://www.ncbi.nlm.nih.gov/pubmed/34260218
http://dx.doi.org/10.1021/acsinfecdis.1c00276

Ejemplares similares

Ejemplares similares