Filling in the gaps: SNX-RGS proteins as multiorganelle tethers

SNX-RGS proteins are molecular tethers localized to multiple interorganelle contact sites that exhibit roles in cellular metabolism. Here, we highlight recent findings on these proteins and discuss their emerging roles in metabolism, human disease, and lipid trafficking.

Detalles Bibliográficos
Autores principales: Hariri, Hanaa, Henne, W. Mike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996316/
https://www.ncbi.nlm.nih.gov/pubmed/35389422
http://dx.doi.org/10.1083/jcb.202203061
Descripción
Sumario:SNX-RGS proteins are molecular tethers localized to multiple interorganelle contact sites that exhibit roles in cellular metabolism. Here, we highlight recent findings on these proteins and discuss their emerging roles in metabolism, human disease, and lipid trafficking.

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