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Characterizing multiscale modular structures in medication‐free obsessive–compulsive disorder patients with no comorbidity

Brain networks exhibit signatures of modular structure, which maintains a fine trade‐off between wiring cost and efficiency of information transmission. Alterations in modular structure have been found in patients with obsessive–compulsive disorder (OCD). However, previous studies were focused on a...

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Autores principales: Li, Xue, Li, Hailong, Jiang, Xi, Li, Jing, Cao, Lingxiao, Liu, Jing, Xing, Haoyang, Huang, Xiaoqi, Gong, Qiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996347/
https://www.ncbi.nlm.nih.gov/pubmed/35170143
http://dx.doi.org/10.1002/hbm.25794
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author Li, Xue
Li, Hailong
Jiang, Xi
Li, Jing
Cao, Lingxiao
Liu, Jing
Xing, Haoyang
Huang, Xiaoqi
Gong, Qiyong
author_facet Li, Xue
Li, Hailong
Jiang, Xi
Li, Jing
Cao, Lingxiao
Liu, Jing
Xing, Haoyang
Huang, Xiaoqi
Gong, Qiyong
author_sort Li, Xue
collection PubMed
description Brain networks exhibit signatures of modular structure, which maintains a fine trade‐off between wiring cost and efficiency of information transmission. Alterations in modular structure have been found in patients with obsessive–compulsive disorder (OCD). However, previous studies were focused on a single scale (i.e., modularity or intra/intermodular connectivity) for investigation. Here, we recruited 92 OCD patients and 90 healthy controls. A comprehensive analysis was performed on modular architecture alterations in the voxelwise functional connectome at the “global” (modularity), “meso” (modular segregation and within‐ and between‐module connections), and “local” (participation coefficients, PC) scales. We also examined the correlation between modular structure metrics and clinical symptoms. The findings revealed that (1) there was no significant group difference in global modularity; (2) both primary modules (visual network, sensorimotor network) and high‐order modules (dorsal attention network, frontoparietal network) exhibited lower modular segregation in OCD patients, which was mainly driven by increased numbers of between‐module connections; and (3) OCD patients showed higher PC in several connectors including the bilateral middle occipital gyri, left medial orbital frontal gyrus, left superior frontal gyrus, left posterior cingulate gyrus, right superior temporal gyrus and right middle frontal gyrus, and lower PC in the right lingual gyrus. Moreover, these alterations in modular structure were associated with clinical symptoms in patients. Our findings provide further insights into the involvement of different modules in functional network dysfunction in OCD from a connectomic perspective and suggest a synergetic mechanism of module interactions that may be related to the pathophysiology of OCD.
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spelling pubmed-89963472022-04-15 Characterizing multiscale modular structures in medication‐free obsessive–compulsive disorder patients with no comorbidity Li, Xue Li, Hailong Jiang, Xi Li, Jing Cao, Lingxiao Liu, Jing Xing, Haoyang Huang, Xiaoqi Gong, Qiyong Hum Brain Mapp Research Articles Brain networks exhibit signatures of modular structure, which maintains a fine trade‐off between wiring cost and efficiency of information transmission. Alterations in modular structure have been found in patients with obsessive–compulsive disorder (OCD). However, previous studies were focused on a single scale (i.e., modularity or intra/intermodular connectivity) for investigation. Here, we recruited 92 OCD patients and 90 healthy controls. A comprehensive analysis was performed on modular architecture alterations in the voxelwise functional connectome at the “global” (modularity), “meso” (modular segregation and within‐ and between‐module connections), and “local” (participation coefficients, PC) scales. We also examined the correlation between modular structure metrics and clinical symptoms. The findings revealed that (1) there was no significant group difference in global modularity; (2) both primary modules (visual network, sensorimotor network) and high‐order modules (dorsal attention network, frontoparietal network) exhibited lower modular segregation in OCD patients, which was mainly driven by increased numbers of between‐module connections; and (3) OCD patients showed higher PC in several connectors including the bilateral middle occipital gyri, left medial orbital frontal gyrus, left superior frontal gyrus, left posterior cingulate gyrus, right superior temporal gyrus and right middle frontal gyrus, and lower PC in the right lingual gyrus. Moreover, these alterations in modular structure were associated with clinical symptoms in patients. Our findings provide further insights into the involvement of different modules in functional network dysfunction in OCD from a connectomic perspective and suggest a synergetic mechanism of module interactions that may be related to the pathophysiology of OCD. John Wiley & Sons, Inc. 2022-02-16 /pmc/articles/PMC8996347/ /pubmed/35170143 http://dx.doi.org/10.1002/hbm.25794 Text en © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Li, Xue
Li, Hailong
Jiang, Xi
Li, Jing
Cao, Lingxiao
Liu, Jing
Xing, Haoyang
Huang, Xiaoqi
Gong, Qiyong
Characterizing multiscale modular structures in medication‐free obsessive–compulsive disorder patients with no comorbidity
title Characterizing multiscale modular structures in medication‐free obsessive–compulsive disorder patients with no comorbidity
title_full Characterizing multiscale modular structures in medication‐free obsessive–compulsive disorder patients with no comorbidity
title_fullStr Characterizing multiscale modular structures in medication‐free obsessive–compulsive disorder patients with no comorbidity
title_full_unstemmed Characterizing multiscale modular structures in medication‐free obsessive–compulsive disorder patients with no comorbidity
title_short Characterizing multiscale modular structures in medication‐free obsessive–compulsive disorder patients with no comorbidity
title_sort characterizing multiscale modular structures in medication‐free obsessive–compulsive disorder patients with no comorbidity
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996347/
https://www.ncbi.nlm.nih.gov/pubmed/35170143
http://dx.doi.org/10.1002/hbm.25794
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