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The Impact of Age on Propofol Requirement for Inducing Loss of Consciousness in Elderly Surgical Patients

It is generally accepted that geriatric patients are more sensitive to propofol than adults; thus, a dose-adjusted propofol is recommended for these patients during the induction of anesthesia. However, for patients aged 75 years and over, established guidelines for propofol induction doses do not p...

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Autores principales: Yang, Hua, Deng, Hui-Min, Chen, Hai-Yan, Tang, Shu-Heng, Deng, Fang, Lu, Yu-Gang, Song, Jin-Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996377/
https://www.ncbi.nlm.nih.gov/pubmed/35418861
http://dx.doi.org/10.3389/fphar.2022.739552
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author Yang, Hua
Deng, Hui-Min
Chen, Hai-Yan
Tang, Shu-Heng
Deng, Fang
Lu, Yu-Gang
Song, Jin-Chao
author_facet Yang, Hua
Deng, Hui-Min
Chen, Hai-Yan
Tang, Shu-Heng
Deng, Fang
Lu, Yu-Gang
Song, Jin-Chao
author_sort Yang, Hua
collection PubMed
description It is generally accepted that geriatric patients are more sensitive to propofol than adults; thus, a dose-adjusted propofol is recommended for these patients during the induction of anesthesia. However, for patients aged 75 years and over, established guidelines for propofol induction doses do not provide dose references. To this end, we observed 80 surgical patients (female 39, male 41, American Society of Anesthesiologists physical status score I ∼ II) to access the appropriate dose of propofol for inducing loss of consciousness (LOC). Accordingly, patients were subdivided into group A (20 patients, 45–64 years), group B (20 patients, 65–74 years), group C (20 patients, 75–84 years), and group D (20 patients, ≥ 85 years). All patients received propofol (at a rate of 0.3 mg/kg/min) alone for inducing LOC, which was defined by loss of both eyelash reflex and verbal response. Compared with group A, the propofol requirement for LOC in Group B, C and D decreased by 14.8, 25.2 and 38.5%, respectively. Bivariate linear correlation analysis showed that propofol requirement was negatively correlated with age. After adjusting for potential confounders, age was still an independent factor affecting propofol requirement. In conclusion, the propofol requirement for inducing LOC decreased significantly in elderly patients. We demonstrated that age was an independent factor impacting propofol requirement for LOC during the induction of general anesthesia, implying that the propofol dose for anesthesia induction should be further reduced in elderly surgical patients, especially those aged 75 years and over.
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spelling pubmed-89963772022-04-12 The Impact of Age on Propofol Requirement for Inducing Loss of Consciousness in Elderly Surgical Patients Yang, Hua Deng, Hui-Min Chen, Hai-Yan Tang, Shu-Heng Deng, Fang Lu, Yu-Gang Song, Jin-Chao Front Pharmacol Pharmacology It is generally accepted that geriatric patients are more sensitive to propofol than adults; thus, a dose-adjusted propofol is recommended for these patients during the induction of anesthesia. However, for patients aged 75 years and over, established guidelines for propofol induction doses do not provide dose references. To this end, we observed 80 surgical patients (female 39, male 41, American Society of Anesthesiologists physical status score I ∼ II) to access the appropriate dose of propofol for inducing loss of consciousness (LOC). Accordingly, patients were subdivided into group A (20 patients, 45–64 years), group B (20 patients, 65–74 years), group C (20 patients, 75–84 years), and group D (20 patients, ≥ 85 years). All patients received propofol (at a rate of 0.3 mg/kg/min) alone for inducing LOC, which was defined by loss of both eyelash reflex and verbal response. Compared with group A, the propofol requirement for LOC in Group B, C and D decreased by 14.8, 25.2 and 38.5%, respectively. Bivariate linear correlation analysis showed that propofol requirement was negatively correlated with age. After adjusting for potential confounders, age was still an independent factor affecting propofol requirement. In conclusion, the propofol requirement for inducing LOC decreased significantly in elderly patients. We demonstrated that age was an independent factor impacting propofol requirement for LOC during the induction of general anesthesia, implying that the propofol dose for anesthesia induction should be further reduced in elderly surgical patients, especially those aged 75 years and over. Frontiers Media S.A. 2022-03-28 /pmc/articles/PMC8996377/ /pubmed/35418861 http://dx.doi.org/10.3389/fphar.2022.739552 Text en Copyright © 2022 Yang, Deng, Chen, Tang, Deng, Lu and Song. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Yang, Hua
Deng, Hui-Min
Chen, Hai-Yan
Tang, Shu-Heng
Deng, Fang
Lu, Yu-Gang
Song, Jin-Chao
The Impact of Age on Propofol Requirement for Inducing Loss of Consciousness in Elderly Surgical Patients
title The Impact of Age on Propofol Requirement for Inducing Loss of Consciousness in Elderly Surgical Patients
title_full The Impact of Age on Propofol Requirement for Inducing Loss of Consciousness in Elderly Surgical Patients
title_fullStr The Impact of Age on Propofol Requirement for Inducing Loss of Consciousness in Elderly Surgical Patients
title_full_unstemmed The Impact of Age on Propofol Requirement for Inducing Loss of Consciousness in Elderly Surgical Patients
title_short The Impact of Age on Propofol Requirement for Inducing Loss of Consciousness in Elderly Surgical Patients
title_sort impact of age on propofol requirement for inducing loss of consciousness in elderly surgical patients
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996377/
https://www.ncbi.nlm.nih.gov/pubmed/35418861
http://dx.doi.org/10.3389/fphar.2022.739552
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