Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance

Multidrug resistance (MDR) is one of the main impediments in successful chemotherapy in cancer treatment. Overexpression of ATP-binding cassette (ABC) transporter proteins is one of the most important mechanisms of MDR. Natural products have their unique advantages in reversing MDR, among which dite...

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Detalles Bibliográficos
Autores principales: Deng, Zhuo-fen, Bakunina, Irina, Yu, Hua, Han, Jaehong, Dömling, Alexander, Ferreira, Maria-José U, Zhang, Jian-ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996378/
https://www.ncbi.nlm.nih.gov/pubmed/35418870
http://dx.doi.org/10.3389/fphar.2022.815603
Descripción
Sumario:Multidrug resistance (MDR) is one of the main impediments in successful chemotherapy in cancer treatment. Overexpression of ATP-binding cassette (ABC) transporter proteins is one of the most important mechanisms of MDR. Natural products have their unique advantages in reversing MDR, among which diterpenoids have attracted great attention of the researchers around the world. This review article summarizes and discusses the research progress on diterpenoids in reversing MDR.

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