Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance

Multidrug resistance (MDR) is one of the main impediments in successful chemotherapy in cancer treatment. Overexpression of ATP-binding cassette (ABC) transporter proteins is one of the most important mechanisms of MDR. Natural products have their unique advantages in reversing MDR, among which dite...

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Autores principales: Deng, Zhuo-fen, Bakunina, Irina, Yu, Hua, Han, Jaehong, Dömling, Alexander, Ferreira, Maria-José U, Zhang, Jian-ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996378/
https://www.ncbi.nlm.nih.gov/pubmed/35418870
http://dx.doi.org/10.3389/fphar.2022.815603
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author Deng, Zhuo-fen
Bakunina, Irina
Yu, Hua
Han, Jaehong
Dömling, Alexander
Ferreira, Maria-José U
Zhang, Jian-ye
author_facet Deng, Zhuo-fen
Bakunina, Irina
Yu, Hua
Han, Jaehong
Dömling, Alexander
Ferreira, Maria-José U
Zhang, Jian-ye
author_sort Deng, Zhuo-fen
collection PubMed
description Multidrug resistance (MDR) is one of the main impediments in successful chemotherapy in cancer treatment. Overexpression of ATP-binding cassette (ABC) transporter proteins is one of the most important mechanisms of MDR. Natural products have their unique advantages in reversing MDR, among which diterpenoids have attracted great attention of the researchers around the world. This review article summarizes and discusses the research progress on diterpenoids in reversing MDR.
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spelling pubmed-89963782022-04-12 Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance Deng, Zhuo-fen Bakunina, Irina Yu, Hua Han, Jaehong Dömling, Alexander Ferreira, Maria-José U Zhang, Jian-ye Front Pharmacol Pharmacology Multidrug resistance (MDR) is one of the main impediments in successful chemotherapy in cancer treatment. Overexpression of ATP-binding cassette (ABC) transporter proteins is one of the most important mechanisms of MDR. Natural products have their unique advantages in reversing MDR, among which diterpenoids have attracted great attention of the researchers around the world. This review article summarizes and discusses the research progress on diterpenoids in reversing MDR. Frontiers Media S.A. 2022-03-28 /pmc/articles/PMC8996378/ /pubmed/35418870 http://dx.doi.org/10.3389/fphar.2022.815603 Text en Copyright © 2022 Deng, Bakunina, Yu, Han, Dömling, Ferreira and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Deng, Zhuo-fen
Bakunina, Irina
Yu, Hua
Han, Jaehong
Dömling, Alexander
Ferreira, Maria-José U
Zhang, Jian-ye
Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance
title Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance
title_full Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance
title_fullStr Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance
title_full_unstemmed Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance
title_short Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance
title_sort research progress on natural diterpenoids in reversing multidrug resistance
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996378/
https://www.ncbi.nlm.nih.gov/pubmed/35418870
http://dx.doi.org/10.3389/fphar.2022.815603
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