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Expansion of the prime editing modality with Cas9 from Francisella novicida

Prime editing can induce a desired base substitution, insertion, or deletion in a target gene using reverse transcriptase after nick formation by CRISPR nickase. In this study, we develop a technology that can be used to insert or replace external bases in the target DNA sequence by linking reverse...

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Detalles Bibliográficos
Autores principales:	Oh, Yeounsun, Lee, Wi-jae, Hur, Junho K., Song, Woo Jeung, Lee, Youngjeon, Kim, Hanseop, Gwon, Lee Wha, Kim, Young-Hyun, Park, Young-Ho, Kim, Chan Hyoung, Lim, Kyung-Seob, Song, Bong-Seok, Huh, Jae-Won, Kim, Sun-Uk, Jun, Bong-Hyun, Jung, Cheulhee, Lee, Seung Hwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996390/ https://www.ncbi.nlm.nih.gov/pubmed/35410288 http://dx.doi.org/10.1186/s13059-022-02644-8

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