Ganetespib selectively sensitizes cancer cells for proximal and distal spread-out Bragg peak proton irradiation

OBJECTIVE: Hypersensitivity towards proton versus photon irradiation was demonstrated in homologous recombination repair (HRR)-deficient cell lines. Hence, combined treatment concepts targeting HRR provide a rational for potential pharmaceutical exploitation. The HSP90 inhibitor ganetespib (STA-9090...

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Detalles Bibliográficos
Autores principales: Deycmar, Simon, Mara, Elisabeth, Kerschbaum-Gruber, Sylvia, Waller, Verena, Georg, Dietmar, Pruschy, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996402/
https://www.ncbi.nlm.nih.gov/pubmed/35410422
http://dx.doi.org/10.1186/s13014-022-02036-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996402/
https://www.ncbi.nlm.nih.gov/pubmed/35410422
http://dx.doi.org/10.1186/s13014-022-02036-z

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