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Sense of Coherence Mediates the Relationship Between Cognitive Reserve and Cognition in Middle-Aged Adults

In recent years, supported by new scientific evidence, the conceptualization of cognitive reserve (CR) has been progressively enriched and now encompasses not only cognitive stimulating activities or educational level, but also lifestyle activities, such as leisure physical activity and socializatio...

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Autores principales: Cattaneo, Gabriele, Solana-Sánchez, Javier, Abellaneda-Pérez, Kilian, Portellano-Ortiz, Cristina, Delgado-Gallén, Selma, Alviarez Schulze, Vanessa, Pachón-García, Catherine, Zetterberg, H., Tormos, Jose Maria, Pascual-Leone, Alvaro, Bartrés-Faz, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996461/
https://www.ncbi.nlm.nih.gov/pubmed/35418913
http://dx.doi.org/10.3389/fpsyg.2022.835415
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author Cattaneo, Gabriele
Solana-Sánchez, Javier
Abellaneda-Pérez, Kilian
Portellano-Ortiz, Cristina
Delgado-Gallén, Selma
Alviarez Schulze, Vanessa
Pachón-García, Catherine
Zetterberg, H.
Tormos, Jose Maria
Pascual-Leone, Alvaro
Bartrés-Faz, David
author_facet Cattaneo, Gabriele
Solana-Sánchez, Javier
Abellaneda-Pérez, Kilian
Portellano-Ortiz, Cristina
Delgado-Gallén, Selma
Alviarez Schulze, Vanessa
Pachón-García, Catherine
Zetterberg, H.
Tormos, Jose Maria
Pascual-Leone, Alvaro
Bartrés-Faz, David
author_sort Cattaneo, Gabriele
collection PubMed
description In recent years, supported by new scientific evidence, the conceptualization of cognitive reserve (CR) has been progressively enriched and now encompasses not only cognitive stimulating activities or educational level, but also lifestyle activities, such as leisure physical activity and socialization. In this context, there is increasing interest in understanding the role of psychological factors in brain health and cognitive functioning. In a previous study, we have found that these factors mediated the relationship between CR and self-reported cognitive functioning. In this study, we have confirmed an association between two important constructs included in the psychological wellbeing and salutogenic models, “purpose in life” and “sense of coherence,” CR, as assessed using a questionnaire, and cognitive functioning, as evaluated using a comprehensive neuropsychological battery. Results from 888 middle-aged healthy participants from the Barcelona Brain Health Initiative indicate that both sense of coherence (SoC) and CR were positively associated with verbal memory, reasoning and attention, working memory, and global cognition. Moreover, the relation between CR and cognitive functioning in the different domains is partially mediated by SoC. When we controlled for brain integrity, introducing into the model neurofilament light chain measures, the mediator role of SoC was confirmed for reasoning and attention and global cognition. However, purpose in life was not associated with cognitive functioning. These results reveal the central role of the SoC construct, which mediates the association between classic CR estimates and cognitive functions, potentially representing a modifiable target for interventions that aim to promote brain health.
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spelling pubmed-89964612022-04-12 Sense of Coherence Mediates the Relationship Between Cognitive Reserve and Cognition in Middle-Aged Adults Cattaneo, Gabriele Solana-Sánchez, Javier Abellaneda-Pérez, Kilian Portellano-Ortiz, Cristina Delgado-Gallén, Selma Alviarez Schulze, Vanessa Pachón-García, Catherine Zetterberg, H. Tormos, Jose Maria Pascual-Leone, Alvaro Bartrés-Faz, David Front Psychol Psychology In recent years, supported by new scientific evidence, the conceptualization of cognitive reserve (CR) has been progressively enriched and now encompasses not only cognitive stimulating activities or educational level, but also lifestyle activities, such as leisure physical activity and socialization. In this context, there is increasing interest in understanding the role of psychological factors in brain health and cognitive functioning. In a previous study, we have found that these factors mediated the relationship between CR and self-reported cognitive functioning. In this study, we have confirmed an association between two important constructs included in the psychological wellbeing and salutogenic models, “purpose in life” and “sense of coherence,” CR, as assessed using a questionnaire, and cognitive functioning, as evaluated using a comprehensive neuropsychological battery. Results from 888 middle-aged healthy participants from the Barcelona Brain Health Initiative indicate that both sense of coherence (SoC) and CR were positively associated with verbal memory, reasoning and attention, working memory, and global cognition. Moreover, the relation between CR and cognitive functioning in the different domains is partially mediated by SoC. When we controlled for brain integrity, introducing into the model neurofilament light chain measures, the mediator role of SoC was confirmed for reasoning and attention and global cognition. However, purpose in life was not associated with cognitive functioning. These results reveal the central role of the SoC construct, which mediates the association between classic CR estimates and cognitive functions, potentially representing a modifiable target for interventions that aim to promote brain health. Frontiers Media S.A. 2022-03-28 /pmc/articles/PMC8996461/ /pubmed/35418913 http://dx.doi.org/10.3389/fpsyg.2022.835415 Text en Copyright © 2022 Cattaneo, Solana-Sánchez, Abellaneda-Pérez, Portellano-Ortiz, Delgado-Gallén, Alviarez Schulze, Pachón-García, Zetterberg, Tormos, Pascual-Leone and Bartrés-Faz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Cattaneo, Gabriele
Solana-Sánchez, Javier
Abellaneda-Pérez, Kilian
Portellano-Ortiz, Cristina
Delgado-Gallén, Selma
Alviarez Schulze, Vanessa
Pachón-García, Catherine
Zetterberg, H.
Tormos, Jose Maria
Pascual-Leone, Alvaro
Bartrés-Faz, David
Sense of Coherence Mediates the Relationship Between Cognitive Reserve and Cognition in Middle-Aged Adults
title Sense of Coherence Mediates the Relationship Between Cognitive Reserve and Cognition in Middle-Aged Adults
title_full Sense of Coherence Mediates the Relationship Between Cognitive Reserve and Cognition in Middle-Aged Adults
title_fullStr Sense of Coherence Mediates the Relationship Between Cognitive Reserve and Cognition in Middle-Aged Adults
title_full_unstemmed Sense of Coherence Mediates the Relationship Between Cognitive Reserve and Cognition in Middle-Aged Adults
title_short Sense of Coherence Mediates the Relationship Between Cognitive Reserve and Cognition in Middle-Aged Adults
title_sort sense of coherence mediates the relationship between cognitive reserve and cognition in middle-aged adults
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996461/
https://www.ncbi.nlm.nih.gov/pubmed/35418913
http://dx.doi.org/10.3389/fpsyg.2022.835415
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