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Association of epicardial adipose tissue with the severity and adverse clinical outcomes of COVID-19: A meta-analysis
OBJECTIVES: Epicardial adipose tissue (EAT) has been proposed to be an independent predictor of visceral adiposity. EAT measures are associated with coronary artery disease, diabetes, and chronic obstructive pulmonary disease, which are risk factors for COVID-19 poor prognosis. Whether EAT measures...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996473/ https://www.ncbi.nlm.nih.gov/pubmed/35421580 http://dx.doi.org/10.1016/j.ijid.2022.04.013 |
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author | Liu, Kaiwei Wang, Xin Song, Guang |
author_facet | Liu, Kaiwei Wang, Xin Song, Guang |
author_sort | Liu, Kaiwei |
collection | PubMed |
description | OBJECTIVES: Epicardial adipose tissue (EAT) has been proposed to be an independent predictor of visceral adiposity. EAT measures are associated with coronary artery disease, diabetes, and chronic obstructive pulmonary disease, which are risk factors for COVID-19 poor prognosis. Whether EAT measures are related to COVID-19 severity and prognosis is controversial. METHODS: We searched 6 databases for studies until January 7, 2022. The pooled effects are presented as the standard mean difference (SMD) or weighted mean difference with 95% confidence intervals (CIs). The primary end point was COVID-19 severity. Adverse clinical outcomes were also assessed. RESULTS: A total of 13 studies with 2482 patients with COVID-19 were identified. All patients had positive reverse transcriptase-polymerase chain reaction results. All quantitative EAT measures were based on computed tomography. Patients in the severe group had higher EAT measures compared with the nonsevere group (SMD = 0.74, 95% CI: 0.29–1.18, P = 0.001). Patients with hospitalization requirement, requiring invasive mechanical ventilation, admitted to intensive care unit, or with combined adverse outcomes had higher EAT measures compared to their controls (all P < 0.001). CONCLUSIONS: EAT measures were associated with the severity and adverse clinical outcomes of COVID-19. EAT measures might help in prognostic risk stratification of patients with COVID-19. |
format | Online Article Text |
id | pubmed-8996473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89964732022-04-11 Association of epicardial adipose tissue with the severity and adverse clinical outcomes of COVID-19: A meta-analysis Liu, Kaiwei Wang, Xin Song, Guang Int J Infect Dis Article OBJECTIVES: Epicardial adipose tissue (EAT) has been proposed to be an independent predictor of visceral adiposity. EAT measures are associated with coronary artery disease, diabetes, and chronic obstructive pulmonary disease, which are risk factors for COVID-19 poor prognosis. Whether EAT measures are related to COVID-19 severity and prognosis is controversial. METHODS: We searched 6 databases for studies until January 7, 2022. The pooled effects are presented as the standard mean difference (SMD) or weighted mean difference with 95% confidence intervals (CIs). The primary end point was COVID-19 severity. Adverse clinical outcomes were also assessed. RESULTS: A total of 13 studies with 2482 patients with COVID-19 were identified. All patients had positive reverse transcriptase-polymerase chain reaction results. All quantitative EAT measures were based on computed tomography. Patients in the severe group had higher EAT measures compared with the nonsevere group (SMD = 0.74, 95% CI: 0.29–1.18, P = 0.001). Patients with hospitalization requirement, requiring invasive mechanical ventilation, admitted to intensive care unit, or with combined adverse outcomes had higher EAT measures compared to their controls (all P < 0.001). CONCLUSIONS: EAT measures were associated with the severity and adverse clinical outcomes of COVID-19. EAT measures might help in prognostic risk stratification of patients with COVID-19. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2022-07 2022-04-11 /pmc/articles/PMC8996473/ /pubmed/35421580 http://dx.doi.org/10.1016/j.ijid.2022.04.013 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Liu, Kaiwei Wang, Xin Song, Guang Association of epicardial adipose tissue with the severity and adverse clinical outcomes of COVID-19: A meta-analysis |
title | Association of epicardial adipose tissue with the severity and adverse clinical outcomes of COVID-19: A meta-analysis |
title_full | Association of epicardial adipose tissue with the severity and adverse clinical outcomes of COVID-19: A meta-analysis |
title_fullStr | Association of epicardial adipose tissue with the severity and adverse clinical outcomes of COVID-19: A meta-analysis |
title_full_unstemmed | Association of epicardial adipose tissue with the severity and adverse clinical outcomes of COVID-19: A meta-analysis |
title_short | Association of epicardial adipose tissue with the severity and adverse clinical outcomes of COVID-19: A meta-analysis |
title_sort | association of epicardial adipose tissue with the severity and adverse clinical outcomes of covid-19: a meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996473/ https://www.ncbi.nlm.nih.gov/pubmed/35421580 http://dx.doi.org/10.1016/j.ijid.2022.04.013 |
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