Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion

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SARS-CoV-2 infection triggers profound and variable immune responses in human hosts. Chromatin remodeling has been observed in individuals severely ill or convalescing with COVID-19, but chromatin remodeling early in disease prior to anti-spike protein IgG seroconversion has not been defined. We per...

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Detalles Bibliográficos
Autores principales: Giroux, Nicholas S., Ding, Shengli, McClain, Micah T., Burke, Thomas W., Petzold, Elizabeth, Chung, Hong A., Rivera, Grecia O., Wang, Ergang, Xi, Rui, Bose, Shree, Rotstein, Tomer, Nicholson, Bradly P., Chen, Tianyi, Henao, Ricardo, Sempowski, Gregory D., Denny, Thomas N., De Ussel, Maria Iglesias, Satterwhite, Lisa L., Ko, Emily R., Ginsburg, Geoffrey S., Kraft, Bryan D., Tsalik, Ephraim L., Shen, Xiling, Woods, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996625/
https://www.ncbi.nlm.nih.gov/pubmed/35411343
http://dx.doi.org/10.21203/rs.3.rs-1479864/v1
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