Recent Advances in CAR T-Cell Therapy for Patients with Chronic Lymphocytic Leukemia

SIMPLE SUMMARY: Outcomes for patients with chronic lymphocytic leukemia (CLL) have significantly improved over the past decade with the introduction of targeted therapies. These medications have improved survival, with good tolerability. However, for patients in need of treatment who are refractory or intolerant to targeted therapies treatment options are limited and survival is poor. Chimeric antigen receptor T cell therapy (CAR T cell) holds great promise as a potential treatment for patients with high-risk CLL who fail conventional treatment; however, its use to date has been limited. Here we summarize the literature and treatment considerations of CAR T cell therapy for patients with CLL. ABSTRACT: Chimeric antigen receptor T cells (CAR T cells) have resulted in dramatic treatment responses for patients with hematologic malignancies, resulting in improved survival for patients with intractable disease. The first patient treated with CD19 directed CAR T cell therapy had chronic lymphocytic leukemia (CLL) and achieved a complete remission. Subsequent clinical trials have focused largely on patients with other B-cell hematologic malignancies, owing to the fact that CAR T cell therapy for patients with CLL has met with challenges. More recent clinical trials have demonstrated CAR T cell therapy can be well tolerated and effective for patients with CLL, making it a potential treatment option for patients with this disease. In this article we review the background on CAR T cells for the treatment of patients with CLL, focusing on the unique obstacles that patients with CLL present for the development of adoptive T cell therapy, and the novel approaches currently under development to overcome these hurdles.