Use of Venetoclax in Patients with Relapsed or Refractory Acute Myeloid Leukemia: The PETHEMA Registry Experience

SIMPLE SUMMARY: The use of venetoclax combined with hypomethylating agents or low-dose cytarabine in patients with newly diagnosed acute myeloid leukemia unfit for intensive chemotherapy was recently approved. However, the evidence in relapse or refractory patients is still scarce. The cohort of pat...

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Detalles Bibliográficos
Autores principales: Labrador, Jorge, Saiz-Rodríguez, Miriam, de Miguel, Dunia, de Laiglesia, Almudena, Rodríguez-Medina, Carlos, Vidriales, María Belén, Pérez-Encinas, Manuel, Sánchez-Sánchez, María José, Cuello, Rebeca, Roldán-Pérez, Alicia, Vives, Susana, Benzo-Callejo, Gonzalo, Colorado, Mercedes, García-Fortes, María, Sayas, María José, Olivier, Carmen, Recio, Isabel, Conde-Royo, Diego, Bienert-García, Álvaro, Vahi, María, Muñoz-García, Carmen, Seri-Merino, Cristina, Tormo, Mar, Vall-llovera, Ferran, Foncillas, María-Ángeles, Martínez-Cuadrón, David, Sanz, Miguel Ángel, Montesinos, Pau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997036/
https://www.ncbi.nlm.nih.gov/pubmed/35406512
http://dx.doi.org/10.3390/cancers14071734
Descripción
Sumario:SIMPLE SUMMARY: The use of venetoclax combined with hypomethylating agents or low-dose cytarabine in patients with newly diagnosed acute myeloid leukemia unfit for intensive chemotherapy was recently approved. However, the evidence in relapse or refractory patients is still scarce. The cohort of patients included in our study was heavily pretreated and had a poor performance status. It is still necessary to identify those patients at higher risk of early death who would not benefit from this type of treatment. For these ultra-high-risk patients, other treatment strategies should be followed. ABSTRACT: The effectiveness of venetoclax (VEN) in relapsed or refractory acute myeloid leukemia (RR-AML) has not been well established. This retrospective, multicenter, observational database studied the effectiveness of VEN in a cohort of 51 RR-AML patients and evaluated for predictors of response and overall survival (OS). The median age was 68 years, most were at high risk, 61% received ≥2 therapies for AML, 49% had received hypomethylating agents, and ECOG was ≥2 in 52%. Complete remission (CR) rate, including CR with incomplete hematological recovery (CRi), was 12.4%. Additionally, 10.4% experienced partial response (PR). The CR/CRi was higher in combination with azacitidine (AZA; 17.9%) than with decitabine (DEC; 6.7%) and low-dose cytarabine (LDAC; 0%). Mutated NPM1 was associated with increased CR/CRi. Median OS was 104 days (95% CI: 56–151). For the combination with AZA, DEC, and LDAC, median OS was 120 days, 104 days, and 69 days, respectively; p = 0.875. Treatment response and ECOG 0 influenced OS in a multivariate model. A total of 28% of patients required interruption of VEN because of toxicity. Our real-life series describes a marginal probability of CR/CRi and poor OS after VEN-based salvage. Patients included had very poor-risk features and were heavily pretreated. The small percentage of responders did not reach the median OS.

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