Cargando…

Inhibition of MACC1-Induced Metastasis in Esophageal and Gastric Adenocarcinomas

SIMPLE SUMMARY: Esophageal and Gastric Adenocarcinomas (AGE/S) are characterized by early metastasis and poor survival. MACC1 (Metastasis Associated in Colon Cancer 1) acts in colon cancer as a metastasis inducer and is linked to reduced survival. In this study, we analyzed the prognostic role of MA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Treese, Christoph, Werchan, Jessica, von Winterfeld, Moritz, Berg, Erika, Hummel, Michael, Timm, Lena, Rau, Beate, Daberkow, Ole, Walther, Wolfgang, Daum, Severin, Kobelt, Dennis, Stein, Ulrike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997092/ https://www.ncbi.nlm.nih.gov/pubmed/35406545 http://dx.doi.org/10.3390/cancers14071773

Ejemplares similares

S100A4 Is a Strong Negative Prognostic Marker and Potential Therapeutic Target in Adenocarcinoma of the Stomach and Esophagus
por: Treese, Christoph, et al.
Publicado: (2022)

Prognostic impact of Claudin 18.2 in gastric and esophageal adenocarcinomas
por: Arnold, A., et al.
Publicado: (2020)

Prognostic impact of activin subunit inhibin beta A in gastric and esophageal adenocarcinomas
por: Staudacher, J. J., et al.
Publicado: (2022)

Restoring Treatment Response in Colorectal Cancer Cells by Targeting MACC1-Dependent ABCB1 Expression in Combination Therapy
por: Dahlmann, Mathias, et al.
Publicado: (2020)

Better prognosis of gastric cancer patients with high levels of tumor infiltrating lymphocytes is counteracted by PD-1 expression
por: Pötzsch, M., et al.
Publicado: (2020)

Poorly Differentiated Medullary Phenotype Predicts Poor Survival in Early Lymph Node-Negative Gastro-Esophageal Adenocarcinomas
por: Treese, Christoph, et al.
Publicado: (2016)

Saffron Crudes and Compounds Restrict MACC1-Dependent Cell Proliferation and Migration of Colorectal Cancer Cells
por: Güllü, Nazli, et al.
Publicado: (2020)

Systematic Identification of MACC1-Driven Metabolic Networks in Colorectal Cancer
por: Lisec, Jan, et al.
Publicado: (2021)

MACC1-Induced Collective Migration Is Promoted by Proliferation Rather Than Single Cell Biomechanics
por: Hohmann, Tim, et al.
Publicado: (2022)

MACC1 driven alterations in cellular biomechanics facilitate cell motility in glioblastoma
por: Hohmann, Tim, et al.
Publicado: (2020)

Calcium-binding protein S100P is a new target gene of MACC1, drives colorectal cancer metastasis and serves as a prognostic biomarker
por: Schmid, Felicitas, et al.
Publicado: (2022)

Effective Oncoleaking Treatment of Pancreatic Cancer by Claudin-Targeted Suicide Gene Therapy with Clostridium perfringens Enterotoxin (CPE)
por: Pahle, Jessica, et al.
Publicado: (2021)

Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association
por: Bähr, Ina, et al.
Publicado: (2022)

Combinatorial treatment with statins and niclosamide prevents CRC dissemination by unhinging the MACC1-β-catenin-S100A4 axis of metastasis
por: Kortüm, Benedikt, et al.
Publicado: (2022)

Pro-inflammatory TNF-α and IFN-γ Promote Tumor Growth and Metastasis via Induction of MACC1
por: Kobelt, Dennis, et al.
Publicado: (2020)

Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer
por: Link, Theresa, et al.
Publicado: (2019)

Insulin-like Growth Factor Binding Protein-2 (IGFBP2) Is a Key Molecule in the MACC1-Mediated Platelet Communication and Metastasis of Colorectal Cancer Cells
por: Haschemi, Reza, et al.
Publicado: (2021)

Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1
por: Juneja, Manisha, et al.
Publicado: (2017)

Circulating MACC1 Transcripts in Glioblastoma Patients Predict Prognosis and Treatment Response
por: Hagemann, Carsten, et al.
Publicado: (2019)

The newly identified MEK1 tyrosine phosphorylation target MACC1 is druggable by approved MEK1 inhibitors to restrict colorectal cancer metastasis
por: Kobelt, Dennis, et al.
Publicado: (2021)

Frequency of Positive Familial Criteria in Patients with Adenocarcinoma of the Esophageal-Gastric Junction and Stomach: First Prospective Data in a Caucasian Cohort †
por: Schölzchen, Jan, et al.
Publicado: (2022)

MACC1 regulates clathrin-mediated endocytosis and receptor recycling of transferrin receptor and EGFR in colorectal cancer
por: Imbastari, Francesca, et al.
Publicado: (2021)

Elevated MACC1 Expression in Colorectal Cancer Is Driven by Chromosomal Instability and Is Associated with Molecular Subtype and Worse Patient Survival
por: Vuaroqueaux, Vincent, et al.
Publicado: (2022)

Response prediction in patients with gastric and esophagogastric adenocarcinoma under neoadjuvant chemotherapy using targeted gene expression analysis and next-generation sequencing in pre-therapeutic biopsies
por: Kleo, Karsten, et al.
Publicado: (2022)

Hereditary Diffuse Gastric Cancer—Update Based on the Current Consort Recommendations
por: Treese, Christoph, et al.
Publicado: (2022)

MACC1-Dependent Antitumor Effect of Curcumin in Colorectal Cancer
por: Güllü, Nazli, et al.
Publicado: (2022)

Cantharidin and Its Analogue Norcantharidin Inhibit Metastasis—Inducing Genes S100A4 and MACC1
por: Schöpe, Paul Curtis, et al.
Publicado: (2023)

MACC1 is post-transcriptionally regulated by miR-218 in colorectal cancer
por: Ilm, Katharina, et al.
Publicado: (2016)

S100A4 in Cancer Metastasis: Wnt Signaling-Driven Interventions for Metastasis Restriction
por: Dahlmann, Mathias, et al.
Publicado: (2016)

SNPs in the coding region of the metastasis-inducing gene MACC1 and clinical outcome in colorectal cancer
por: Schmid, Felicitas, et al.
Publicado: (2012)

Circulating MACC1 Transcripts in Colorectal Cancer Patient Plasma Predict Metastasis and Prognosis
por: Stein, Ulrike, et al.
Publicado: (2012)

Phase II trial to investigate the safety and efficacy of orally applied niclosamide in patients with metachronous or sychronous metastases of a colorectal cancer progressing after therapy: the NIKOLO trial
por: Burock, Susen, et al.
Publicado: (2018)

Application Route and Immune Status of the Host Determine Safety and Oncolytic Activity of Oncolytic Coxsackievirus B3 Variant PD-H
por: Hazini, Ahmet, et al.
Publicado: (2021)

Increased MACC1 levels in tissues and blood identify colon adenoma patients at high risk
por: Ashktorab, Hassan, et al.
Publicado: (2016)

Core-Clock Genes Regulate Proliferation and Invasion via a Reciprocal Interplay with MACC1 in Colorectal Cancer Cells
por: Basti, Alireza, et al.
Publicado: (2022)

Inflammatory bowel disease (IBD)-like disease in a case of a 33-year old man with glycogenosis 1b
por: Volz, Magdalena Sarah, et al.
Publicado: (2015)

LncRNA MACC1-AS1 associates with DDX5 to modulate MACC1 transcription in breast cancer cells
por: Zheng, Guiyu, et al.
Publicado: (2023)

High MACC1 expression in combination with mutated KRAS G13 indicates poor survival of colorectal cancer patients
por: Ilm, Katharina, et al.
Publicado: (2015)

Small Ones to Fight a Big Problem—Intervention of Cancer Metastasis by Small Molecules
por: Kobelt, Dennis, et al.
Publicado: (2020)

Heterogeneity analysis of Metastasis Associated in Colon Cancer 1 (MACC1) for survival prognosis of colorectal cancer patients: a retrospective cohort study
por: Koelzer, Viktor H, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_bnutift13cn4ur6145cutclaop