Second-Generation JK-206 Targets the Oncogenic Signal Mediator RHOA in Gastric Cancer

SIMPLE SUMMARY: Ras homologous A (RHOA), a signal mediator and a GTPase, is associated with the progression of gastric cancer (GC). We present novel RHOA inhibitors designed for greater anti-GC potency by means of lead optimization. The RHOA → BIRC5 signaling circuit was found to be a new therapeuti...

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Detalles Bibliográficos
Autores principales: Beak, Myeonghun, Park, Sungjin, Kim, Jin-Hee, Eom, Hyo Jin, Lee, Ho-Yeon, Kim, Yon Hui, Lee, Jinhyuk, Nam, Seungyoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997135/
https://www.ncbi.nlm.nih.gov/pubmed/35406376
http://dx.doi.org/10.3390/cancers14071604

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997135/
https://www.ncbi.nlm.nih.gov/pubmed/35406376
http://dx.doi.org/10.3390/cancers14071604

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