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Second-Generation JK-206 Targets the Oncogenic Signal Mediator RHOA in Gastric Cancer

SIMPLE SUMMARY: Ras homologous A (RHOA), a signal mediator and a GTPase, is associated with the progression of gastric cancer (GC). We present novel RHOA inhibitors designed for greater anti-GC potency by means of lead optimization. The RHOA → BIRC5 signaling circuit was found to be a new therapeuti...

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Detalles Bibliográficos
Autores principales:	Beak, Myeonghun, Park, Sungjin, Kim, Jin-Hee, Eom, Hyo Jin, Lee, Ho-Yeon, Kim, Yon Hui, Lee, Jinhyuk, Nam, Seungyoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997135/ https://www.ncbi.nlm.nih.gov/pubmed/35406376 http://dx.doi.org/10.3390/cancers14071604

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