Association between Socioeconomic Status and Homeostasis Model Assessment-Insulin Resistance Index and Mediating Variables at the First Trimester of Pregnancy

BACKGROUND: Some studies have shown that Socioeconomic Status (SES) is positively related to insulin resistance among different population groups, except for pregnant women. Therefore, we examined the relationship between SES and Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) index as well as mediating variables. MATERIALS AND METHODS: This study was performed on 138 primiparous healthy women at 6–10 weeks of pregnancy. The association between SES and HOMA-IR was analyzed by regression analysis, and mediating variables were determined by mediation analysis. RESULTS: SES score was positively correlated with HOMA-IR index [β = 0.02, t(101) = 2.20, p = 0.03, 95% CI: (0.00–0.05]. The higher percentage of mediation was related to maternal weigh (70.80%). Job activity had a protective effect on the association between SES and HOMA-IR (-62.50%). The total percentage of two mediators was 25%. CONCLUSIONS: The positive relationship between SES and (HOMA-IR) in early pregnancy may provide a way to control this condition.