Biomimetic human bone marrow tissues: models to study hematopoiesis and platforms for drug testing

We propose an in vitro 3D culture system combining perfusion bioreactors, scaffolds and human primary cells to engineer fully-humanized, biomimetic and customizable bone marrow tissues. This system could serve as a model to investigate human hematopoietic stem cell niches, but also as a drug testing...

Descripción completa

Detalles Bibliográficos
Autores principales: García-García, Andrés, Martin, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997254/
https://www.ncbi.nlm.nih.gov/pubmed/35419486
http://dx.doi.org/10.1080/23723556.2021.2007030
_version_ 1784684662310830080
author García-García, Andrés
Martin, Ivan
author_facet García-García, Andrés
Martin, Ivan
author_sort García-García, Andrés
collection PubMed
description We propose an in vitro 3D culture system combining perfusion bioreactors, scaffolds and human primary cells to engineer fully-humanized, biomimetic and customizable bone marrow tissues. This system could serve as a model to investigate human hematopoietic stem cell niches, but also as a drug testing platform for pharmaceutical research and patient-personalized medicine.
format Online
Article
Text
id pubmed-8997254
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-89972542022-04-12 Biomimetic human bone marrow tissues: models to study hematopoiesis and platforms for drug testing García-García, Andrés Martin, Ivan Mol Cell Oncol Author’s Views We propose an in vitro 3D culture system combining perfusion bioreactors, scaffolds and human primary cells to engineer fully-humanized, biomimetic and customizable bone marrow tissues. This system could serve as a model to investigate human hematopoietic stem cell niches, but also as a drug testing platform for pharmaceutical research and patient-personalized medicine. Taylor & Francis 2021-12-06 /pmc/articles/PMC8997254/ /pubmed/35419486 http://dx.doi.org/10.1080/23723556.2021.2007030 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
García-García, Andrés
Martin, Ivan
Biomimetic human bone marrow tissues: models to study hematopoiesis and platforms for drug testing
title Biomimetic human bone marrow tissues: models to study hematopoiesis and platforms for drug testing
title_full Biomimetic human bone marrow tissues: models to study hematopoiesis and platforms for drug testing
title_fullStr Biomimetic human bone marrow tissues: models to study hematopoiesis and platforms for drug testing
title_full_unstemmed Biomimetic human bone marrow tissues: models to study hematopoiesis and platforms for drug testing
title_short Biomimetic human bone marrow tissues: models to study hematopoiesis and platforms for drug testing
title_sort biomimetic human bone marrow tissues: models to study hematopoiesis and platforms for drug testing
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997254/
https://www.ncbi.nlm.nih.gov/pubmed/35419486
http://dx.doi.org/10.1080/23723556.2021.2007030
work_keys_str_mv AT garciagarciaandres biomimetichumanbonemarrowtissuesmodelstostudyhematopoiesisandplatformsfordrugtesting
AT martinivan biomimetichumanbonemarrowtissuesmodelstostudyhematopoiesisandplatformsfordrugtesting

Ejemplares similares