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Dedifferentiation of esophageal progenitors in metaplasia and cancer
Barrett syndrome is a squamo-columnar metaplasia increasing the risk of developing esophageal adenocarcinoma. Recently, we showed that esophageal cells can transdifferentiate into undifferentiated columnar cells in vivo. Here, we discuss about the potential of these cells to be a reservoir for intes...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997255/ https://www.ncbi.nlm.nih.gov/pubmed/35419482 http://dx.doi.org/10.1080/23723556.2021.1991758 |
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author | Vercauteren Drubbel, Alizée Beck, Benjamin |
author_facet | Vercauteren Drubbel, Alizée Beck, Benjamin |
author_sort | Vercauteren Drubbel, Alizée |
collection | PubMed |
description | Barrett syndrome is a squamo-columnar metaplasia increasing the risk of developing esophageal adenocarcinoma. Recently, we showed that esophageal cells can transdifferentiate into undifferentiated columnar cells in vivo. Here, we discuss about the potential of these cells to be a reservoir for intestinal metaplasia and/or esophageal adenocarcinoma. |
format | Online Article Text |
id | pubmed-8997255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-89972552022-04-12 Dedifferentiation of esophageal progenitors in metaplasia and cancer Vercauteren Drubbel, Alizée Beck, Benjamin Mol Cell Oncol Author’s Views Barrett syndrome is a squamo-columnar metaplasia increasing the risk of developing esophageal adenocarcinoma. Recently, we showed that esophageal cells can transdifferentiate into undifferentiated columnar cells in vivo. Here, we discuss about the potential of these cells to be a reservoir for intestinal metaplasia and/or esophageal adenocarcinoma. Taylor & Francis 2021-10-21 /pmc/articles/PMC8997255/ /pubmed/35419482 http://dx.doi.org/10.1080/23723556.2021.1991758 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Author’s Views Vercauteren Drubbel, Alizée Beck, Benjamin Dedifferentiation of esophageal progenitors in metaplasia and cancer |
title | Dedifferentiation of esophageal progenitors in metaplasia and cancer |
title_full | Dedifferentiation of esophageal progenitors in metaplasia and cancer |
title_fullStr | Dedifferentiation of esophageal progenitors in metaplasia and cancer |
title_full_unstemmed | Dedifferentiation of esophageal progenitors in metaplasia and cancer |
title_short | Dedifferentiation of esophageal progenitors in metaplasia and cancer |
title_sort | dedifferentiation of esophageal progenitors in metaplasia and cancer |
topic | Author’s Views |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997255/ https://www.ncbi.nlm.nih.gov/pubmed/35419482 http://dx.doi.org/10.1080/23723556.2021.1991758 |
work_keys_str_mv | AT vercauterendrubbelalizee dedifferentiationofesophagealprogenitorsinmetaplasiaandcancer AT beckbenjamin dedifferentiationofesophagealprogenitorsinmetaplasiaandcancer |