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Dedifferentiation of esophageal progenitors in metaplasia and cancer

Barrett syndrome is a squamo-columnar metaplasia increasing the risk of developing esophageal adenocarcinoma. Recently, we showed that esophageal cells can transdifferentiate into undifferentiated columnar cells in vivo. Here, we discuss about the potential of these cells to be a reservoir for intes...

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Detalles Bibliográficos
Autores principales: Vercauteren Drubbel, Alizée, Beck, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997255/
https://www.ncbi.nlm.nih.gov/pubmed/35419482
http://dx.doi.org/10.1080/23723556.2021.1991758
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author Vercauteren Drubbel, Alizée
Beck, Benjamin
author_facet Vercauteren Drubbel, Alizée
Beck, Benjamin
author_sort Vercauteren Drubbel, Alizée
collection PubMed
description Barrett syndrome is a squamo-columnar metaplasia increasing the risk of developing esophageal adenocarcinoma. Recently, we showed that esophageal cells can transdifferentiate into undifferentiated columnar cells in vivo. Here, we discuss about the potential of these cells to be a reservoir for intestinal metaplasia and/or esophageal adenocarcinoma.
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spelling pubmed-89972552022-04-12 Dedifferentiation of esophageal progenitors in metaplasia and cancer Vercauteren Drubbel, Alizée Beck, Benjamin Mol Cell Oncol Author’s Views Barrett syndrome is a squamo-columnar metaplasia increasing the risk of developing esophageal adenocarcinoma. Recently, we showed that esophageal cells can transdifferentiate into undifferentiated columnar cells in vivo. Here, we discuss about the potential of these cells to be a reservoir for intestinal metaplasia and/or esophageal adenocarcinoma. Taylor & Francis 2021-10-21 /pmc/articles/PMC8997255/ /pubmed/35419482 http://dx.doi.org/10.1080/23723556.2021.1991758 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author’s Views
Vercauteren Drubbel, Alizée
Beck, Benjamin
Dedifferentiation of esophageal progenitors in metaplasia and cancer
title Dedifferentiation of esophageal progenitors in metaplasia and cancer
title_full Dedifferentiation of esophageal progenitors in metaplasia and cancer
title_fullStr Dedifferentiation of esophageal progenitors in metaplasia and cancer
title_full_unstemmed Dedifferentiation of esophageal progenitors in metaplasia and cancer
title_short Dedifferentiation of esophageal progenitors in metaplasia and cancer
title_sort dedifferentiation of esophageal progenitors in metaplasia and cancer
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997255/
https://www.ncbi.nlm.nih.gov/pubmed/35419482
http://dx.doi.org/10.1080/23723556.2021.1991758
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